Publication
Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery
| dc.contributor.author | Sheeba, Caroline Jeya | |
| dc.contributor.author | Marslin, Gregory | |
| dc.contributor.author | Revina, Ann Mary | |
| dc.contributor.author | Franklin, Gregory | |
| dc.date.accessioned | 2018-12-07T14:52:30Z | |
| dc.date.available | 2018-12-07T14:52:30Z | |
| dc.date.issued | 2014-04 | |
| dc.description.abstract | In the recent years, the "tumor microenvironment" has been receiving growing attention due to its involvement in neoplastic transformation, tumor growth, invasion, and protection of tumor cells from host immune response. All these events are facilitated by chemical signals produced by the tumor as well as the surrounding stromal cells. This review is divided into two main parts in which the first part discusses the receptor tyrosine kinase (RTK)-mediated growth factor signaling, steroid hormone (SH) signaling, ancient signaling pathways, and other molecules that are involved in tumorigenesis and how they interact with each other to create a complex tumor microenvironment. In the second part, we bring together the recent nanocarrier-mediated drug delivery approaches to target the signaling pathways/molecules present in the tumor microenvironment. | |
| dc.description.sponsorship | Foundation for Science and Technology (FCT) [(SFRH/BPD/89493/2012]; FCT [SFRH/BD/72809/2010]; Portuguese Government; FCT national funds (PIDDAC) [PTDC/AGR-GPL/119211/2010, PEst-C/AGR/UI4033/2011]; European Fund for Regional Development (FEDER) through COMPETE Operational Programme Competitive Factors (POFC) | |
| dc.description.version | info:eu-repo/semantics/publishedVersion | |
| dc.identifier.doi | 10.1515/ntrev-2013-0032 | |
| dc.identifier.issn | 2191-9089 | |
| dc.identifier.issn | 2191-9097 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/11093 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Walter de Gruyter Gmbh | |
| dc.relation | SHEDDING LIGHT ON THE CONTROVERSY: ESTABLISHING THE EMBRYO MOLECULAR CLOCK AS AN INTEGRAL COMPONENT OF THE LIMB PATTERNING MACHINERY | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Growth-factor-receptor | |
| dc.subject | Breast-cancer cells | |
| dc.subject | Tyrosine Kinase Inhibitor | |
| dc.subject | Factor-I receptor | |
| dc.subject | Epithelial-Mesenchymal transition | |
| dc.subject | Independent prostate-cancer | |
| dc.subject | Mda-Mb-231 Xenograft growth | |
| dc.subject | Wnt/Beta-Catenin-Pathway | |
| dc.subject | Iron-oxide nanoparticles | |
| dc.subject | Anti-Angiogenic therapy | |
| dc.title | Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | SHEDDING LIGHT ON THE CONTROVERSY: ESTABLISHING THE EMBRYO MOLECULAR CLOCK AS AN INTEGRAL COMPONENT OF THE LIMB PATTERNING MACHINERY | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F89493%2F2012/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F72809%2F2010/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAGR-GPL%2F119211%2F2010/PT | |
| oaire.citation.endPage | 151 | |
| oaire.citation.issue | 2 | |
| oaire.citation.startPage | 123 | |
| oaire.citation.title | Nanotechnology Reviews | |
| oaire.citation.volume | 3 | |
| oaire.fundingStream | SFRH | |
| oaire.fundingStream | COMPETE | |
| person.familyName | Sheeba | |
| person.givenName | Caroline Jeya | |
| person.identifier | 437977 | |
| person.identifier.orcid | 0000-0001-5357-4743 | |
| person.identifier.rid | B-5177-2011 | |
| person.identifier.scopus-author-id | 6504257550 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | |
| rcaap.type | article | |
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