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Phonatory and articulatory representations of speech production in cortical and subcortical fMRI responses

2020Journal article Open access
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dc.contributor.authorCorreia, João
dc.contributor.authorCaballero-Gaudes, César
dc.contributor.authorGuediche, Sara
dc.contributor.authorCarreiras, Manuel
dc.date.accessioned2020-05-20T14:24:00Z
dc.date.available2020-05-20T14:24:00Z
dc.date.issued2020
dc.description.abstractSpeaking involves coordination of multiple neuromotor systems, including respiration, phonation and articulation. Developing non-invasive imaging methods to study how the brain controls these systems is critical for understanding the neurobiology of speech production. Recent models and animal research suggest that regions beyond the primary motor cortex (M1) help orchestrate the neuromotor control needed for speaking, including cortical and sub-cortical regions. Using contrasts between speech conditions with controlled respiratory behavior, this fMRI study investigates articulatory gestures involving the tongue, lips and velum (i.e., alveolars versus bilabials, and nasals versus orals), and phonatory gestures (i.e., voiced versus whispered speech). Multivariate pattern analysis (MVPA) was used to decode articulatory gestures in M1, cerebellum and basal ganglia. Furthermore, apart from confirming the role of a mid-M1 region for phonation, we found that a dorsal M1 region, linked to respiratory control, showed significant differences for voiced compared to whispered speech despite matched lung volume observations. This region was also functionally connected to tongue and lip M1 seed regions, underlying its importance in the coordination of speech. Our study confirms and extends current knowledge regarding the neural mechanisms underlying neuromotor speech control, which hold promise to study neural dysfunctions involved in motor-speech disorders non-invasively.pt_PT
dc.description.sponsorshipTis work was supported by the Spanish Ministry of Economy and Competitiveness through the Juan de la Cierva Fellowship (FJCI-2015-26814), and the Ramon y Cajal Fellowship (RYC-2017- 21845), the Spanish State Research Agency through the BCBL “Severo Ochoa” excellence accreditation (SEV-2015-490), the Basque Government (BERC 2018- 2021) and the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant (No 799554).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41598-020-61435-ypt_PT
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/13916
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectResonance-imaging FMRIpt_PT
dc.subjectInformationpt_PT
dc.subjectMultiple trial typespt_PT
dc.subjectNeuroanatomypt_PT
dc.subjectPrimary motor cortexpt_PT
dc.subjectClassificationpt_PT
dc.subjectOrganizationpt_PT
dc.subjectEvent-related FMRIpt_PT
dc.subjectBrainpt_PT
dc.subjectCerebellumpt_PT
dc.titlePhonatory and articulatory representations of speech production in cortical and subcortical fMRI responsespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage4529pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume10pt_PT
person.familyNameCorreia
person.givenNameJoao
person.identifier.ciencia-id6417-495C-B044
person.identifier.orcid0000-0001-6624-7012
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryaf3ec6e1-51fb-4aa8-8c57-54cb3056f45d

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