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The TERT hypermethylated oncologic region predicts recurrence and survival in pancreatic cancer

2017-10Journal article Restricted access
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dc.contributor.authorFaleiro, Inês
dc.contributor.authorApolónio, Joana
dc.contributor.authorPrice, Aryeh J.
dc.contributor.authorDe Mello, Ramon Andrade
dc.contributor.authorRoberto, Vânia
dc.contributor.authorTabori, Uri
dc.contributor.authorCastelo-Branco, Pedro
dc.date.accessioned2019-11-20T15:07:17Z
dc.date.available2019-11-20T15:07:17Z
dc.date.issued2017-10
dc.description.abstractAim: We explore the biomarker potential of the TERT hypermethylated oncologic region (THOR) in pancreatic cancer. Materials & methods: We assessed the methylation status of THOR using the cancer genome atlas data on the cohort of pancreatic cancer (n = 193 patients). Results: THOR was significantly hypermethylated in pancreatic tumor tissue when compared with the normal tissue used as control (p < 0.0001). Also, THOR hypermethylation could distinguish early stage I disease from normal tissue and was associated with worse prognosis. Discussion: We found that THOR is hypermethylated in pancreatic tumor tissue when compared with normal tissue and that THOR methylation correlates with TERT expression in tumor samples. Conclusion: Our preliminary findings support the diagnostic and prognostic values of THOR in pancreatic cancer.
dc.description.sponsorshipFCT [PD/BD/105899/2014]
dc.description.sponsorshipLPCC-Fundacao PT fellowships
dc.description.sponsorshipCNPQ (Brazilian National Council for Science and Technology, Brasilia, DF, Brazil [402621/2016-6]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.2217/fon-2017-0167
dc.identifier.issn1479-6694
dc.identifier.issn1744-8301
dc.identifier.urihttp://hdl.handle.net/10400.1/12962
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFuture Medicine Lda
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTelomerase
dc.subjectExpression
dc.subjectCarcinoma
dc.titleThe TERT hypermethylated oncologic region predicts recurrence and survival in pancreatic cancer
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2051
oaire.citation.issue23
oaire.citation.startPage2045
oaire.citation.titleFuture Oncology
oaire.citation.volume13
person.familyNameFaleiro
person.familyNameApolónio
person.familyNamede Mello
person.familyNameRoberto
person.familyNameCastelo-Branco
person.givenNameInês
person.givenNameJoana
person.givenNameRamon Andrade
person.givenNameVânia
person.givenNamePedro
person.identifier1230353
person.identifier.ciencia-idAD14-A2D0-3B41
person.identifier.ciencia-id791E-9E39-2795
person.identifier.ciencia-id681E-40B7-331F
person.identifier.ciencia-idE015-7F8F-5CA1
person.identifier.orcid0000-0001-5178-3090
person.identifier.orcid0000-0002-9727-1813
person.identifier.orcid0000-0002-9640-4573
person.identifier.orcid0000-0002-8134-4045
person.identifier.orcid0000-0002-3453-3978
person.identifier.scopus-author-id27467657800
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery01cf2be1-ea9f-4082-bcc6-e50fe4ad9fe1

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