Publication
Acute kidney injury after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a Portuguese population
| dc.contributor.author | Carias, Eduarda | |
| dc.contributor.author | Ferreira, Hugo | |
| dc.contributor.author | Chuva, Teresa | |
| dc.contributor.author | Paiva, Ana | |
| dc.contributor.author | Maximino, Jose | |
| dc.date.accessioned | 2023-03-03T15:21:00Z | |
| dc.date.available | 2023-03-03T15:21:00Z | |
| dc.date.issued | 2022-12 | |
| dc.description.abstract | Background: Acute kidney injury (AKI) after cytoreductive surgery followed by the infusion of hyperthermic intraperitoneal chemothera-py (CRS/HIPEC) is associated with a higher rate of major complica-tions, resulting in prolonged hospitalization and increased mortality. Our objective was to evaluate the incidence of AKI and further pro-gression to chronic kidney disease (CKD) in patients submitted to this procedure and recognize the associated risk factors. Methods: This retrospective study collected demographic, tumor -related, intraoperative, and postoperative data from 182 patients who underwent CRS/HIPEC from January 2016 to December 2019. Re-nal impairment was defined according to Kidney Disease Improv-ing Global Outcomes criteria for AKI. We conducted univariate and multiple logistic regression analyses to assess the association between variables of interest and AKI. Results: Twenty-three patients (12.6%) developed AKI. In the AKI group, the risk for developing CKD was six times higher (odds ra-tio (OR) 6.48, confidence interval (CI) 1.601 -26.255). Multivariate regression identified higher risk of developing AKI in patients who underwent HIPEC with cisplatin (OR 12.21, CI 1.26 -109.70, P = 0.025), in each additional day spent in the intensive care unit (ICU) (OR 2.42, CI 1.07 -5.45, P = 0.033), and an association for each unit increase in estimated glomerular filtration rate (eGFR) before HIPEC (OR 0.96, CI 0.94 -0.98, P = 0.037) and AKI development. Conclusion: Patients who are at higher risk of AKI after CRS/HIPEC include those who performed cisplatin HIPEC regimen, had poorer preoperative renal function and had longer ICU stays. Early institu-tion of preventive measures and frequent monitoring should be considered to minimize AKI risk and its associated morbidity, such as CKD progression. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.14740/wjon1540 | pt_PT |
| dc.identifier.eissn | 1920-454X | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/19194 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | ELMER Press | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Acute kidney injury | pt_PT |
| dc.subject | Intraoperative chemotherapy | pt_PT |
| dc.subject | Nephrotoxicity | pt_PT |
| dc.subject | Platinum agents | pt_PT |
| dc.subject | Chronic kidney disease | pt_PT |
| dc.title | Acute kidney injury after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a Portuguese population | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 378 | pt_PT |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | 370 | pt_PT |
| oaire.citation.title | World Journal of Oncology | pt_PT |
| oaire.citation.volume | 13 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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