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Comparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels

2019-04Journal article Restricted access
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dc.contributor.authorMagro, Fernando
dc.contributor.authorLopes, Joanne
dc.contributor.authorBorralho, Paula
dc.contributor.authorLopes, Susana
dc.contributor.authorCoelho, Rosa
dc.contributor.authorCotter, Jose
dc.contributor.authorde Castro, Francisca Dias
dc.contributor.authorSousa, Helena Tavares
dc.contributor.authorSalgado, Marta
dc.contributor.authorAndrade, Patricia
dc.contributor.authorVieira, Ana Isabel
dc.contributor.authorFigueiredo, Pedro
dc.contributor.authorCaldeira, Paulo
dc.contributor.authorSousa, A.
dc.contributor.authorDuarte, Maria A.
dc.contributor.authorAvila, Filipa
dc.contributor.authorSilva, Joao
dc.contributor.authorMoleiro, Joana
dc.contributor.authorMendes, Sofia
dc.contributor.authorGiestas, Silvia
dc.contributor.authorMinistro, Paula
dc.contributor.authorSousa, Paula
dc.contributor.authorGoncalves, Raquel
dc.contributor.authorGoncalves, Bruno
dc.contributor.authorOliveira, Ana
dc.contributor.authorRosa, Isadora
dc.contributor.authorRodrigues, Marta
dc.contributor.authorChagas, Cristina
dc.contributor.authorDias, Claudia Camila
dc.contributor.authorAfonso, Joana
dc.contributor.authorGeboes, Karel
dc.contributor.authorCarneiro, Fatima
dc.date.accessioned2020-07-24T10:52:31Z
dc.date.available2020-07-24T10:52:31Z
dc.date.issued2019-04
dc.description.abstractObjective Histological remission is being increasingly acknowledged as a therapeutic endpoint in patients with UC. The work hereafter described aimed to evaluate the concordance between three histological classification systems-Geboes Score (GS), Nancy Index (NI) and RobartsHistopathologyIndex (RHI), as well as to evaluate their association with the endoscopic outcomes and the faecal calprotectin (FC) levels. Design Biopsy samples from 377 patients with UC were blindly evaluated using GS, NI and RHI. The results were compared with the patients' Mayo Endoscopic Score and FC levels. Result GS, NI and RHI have a good concordance concerning the distinction between patients in histological remission or activity. RHI was particularly close to NI, with 100% of all patients classified as being in remission with NI being identified as such with RHI and 100% of all patients classified as having activity with RHI being identified as such with NI. These scores could also predict the Mayo Endoscopic Score and the FC levels, with their sensitivity and specificity levels depending on the chosen cut-offs. Moreover, higher FC levels were statistically associated with the presence of neutrophils in the epithelium, as well as with ulceration or erosion of the intestinal mucosa. Conclusions GS, NI and RHI histopathological scoring systems are comparable in what concerns patients' stratification into histological remission/activity. Additionally, FC levels are increased when neutrophils are present in the epithelium and the intestinal mucosa has erosions or ulcers. The presence of neutrophils in the epithelium is, indeed, the main marker of histological activity.
dc.description.sponsorshipPortuguese IBD Group (GEDII-Grupo de Estudo da Doenca Inflamatoria Intestinal)
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1136/gutjnl-2017-315545
dc.identifier.issn0017-5749
dc.identifier.issn1468-3288
dc.identifier.urihttp://hdl.handle.net/10400.1/14370
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBmj Publishing Group
dc.subjectInflammatory-bowel-disease
dc.subjectUlcerative-colitis patients
dc.subjectColorectal neoplasia
dc.subjectRisk-factor
dc.subjectRelapse
dc.subjectBiomarkers
dc.subjectPredictors
dc.subjectInfliximab
dc.subjectDiagnosis
dc.subjectRemission
dc.titleComparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage603
oaire.citation.issue4
oaire.citation.startPage594
oaire.citation.titleGut
oaire.citation.volume68
person.familyNameSousa
person.familyNameCaldeira
person.givenNameHelena Tavares
person.givenNamePaulo
person.identifier.ciencia-idCF1F-1163-1C4A
person.identifier.ciencia-id1112-F0B2-19A3
person.identifier.orcid0000-0002-6626-205X
person.identifier.orcid0000-0002-2404-6295
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication6b1d11dd-486f-4fb3-b41f-02e1cf6a5c2e
relation.isAuthorOfPublication3def3720-8982-4c46-801d-af640d508b59
relation.isAuthorOfPublication.latestForDiscovery3def3720-8982-4c46-801d-af640d508b59

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