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Determinants of health-related quality of life in spondyloarthritis and rheumatoid arthritis - data from the COMOSPA and COMORA studies
dc.contributor.author | Carvalho, Pedro David | |
dc.contributor.author | Vieira-Sousa, Elsa | |
dc.contributor.author | Hmamouchi, Ihsane | |
dc.contributor.author | Marreiros, Ana | |
dc.contributor.author | Machado, Pedro M | |
dc.date.accessioned | 2023-02-09T15:46:49Z | |
dc.date.available | 2023-02-09T15:46:49Z | |
dc.date.issued | 2022-12 | |
dc.description.abstract | Objectives: To assess the hierarchy of outcomes contributing to health-related quality of life (HRQoL) in spondyloarthritis (SpA) and rheumatoid arthritis (RA). Methods: Data from the international cross-sectional COMOSPA and COMORA studies were used. HRQoL was assessed using the EuroQOL 5-dimension 3-level (EQ-5D-3 L). First, multivariable linear regression models were used to identify associations between EQ-5D-3 L (dependent variable) and several demographic and clinical variables (independent variables). Second, a decision tree was built using Chi-square Automatic Interaction Detector, a method of unbiased hierarchical multivariable analysis (dependent variable: EQ-5D-3 L). Results: In total, 3984 patients with SpA and 3920 patients with RA were included. In SpA, HRQoL was associated with BASFI (adjusted B=-0.006; 95%CI=-0.007 to -0.005), ASDAS (-0.052; -0.071 to -0.033), work productivity loss score (-0.002; -0.003 to -0.002), NSAID treatment (-0.052; -0.083 to -0.020), bDMARD treatment (-0.051; -0.082 to -0.021), university education (-0.051; -0.075 to -0.027) and radiographic sacroiliitis (0.035; 0.004 to 0.030). In RA, HRQoL was associated with modified Health Assessment Questionnaire (MHAQ) (-0.220, -0.253 to -0.188), DAS28-CRP-3v (-0.027, -0.036 to -0.018), work productivity loss score (-0.003, -0.003 to -0.002), presence of erosions (-0.042, -0.065 to -0.020), alcohol consumption >= 3 units/day (0.012, 0.001 to 0.024)) and csDMARD treatment (0.034, 0.001 to 0.066). The decision tree revealed BASFI and MHAQ as first variables with the most discriminative power on EQ-5D-3 L, followed by work productivity loss and disease activity, in both SpA and RA cohorts. Conclusion: In SpA and RA, physical function is the main contributor to HRQoL measured by EQ-5D-3 L, followed by disease activity and work productivity loss. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.doi | 10.1016/j.semarthrit.2022.152086 | pt_PT |
dc.identifier.eissn | 1532-866X | |
dc.identifier.uri | http://hdl.handle.net/10400.1/19041 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | Elsevier | pt_PT |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
dc.subject | Spondyloarthritis | pt_PT |
dc.subject | Rheumatoid arthritis | pt_PT |
dc.subject | Physical function | pt_PT |
dc.subject | Disease activity | pt_PT |
dc.subject | Health-related quality of life | pt_PT |
dc.title | Determinants of health-related quality of life in spondyloarthritis and rheumatoid arthritis - data from the COMOSPA and COMORA studies | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.startPage | 152086 | pt_PT |
oaire.citation.title | Seminars in Arthritis and Rheumatism | pt_PT |
oaire.citation.volume | 57 | pt_PT |
person.familyName | Marreiros | |
person.givenName | Ana | |
person.identifier.ciencia-id | 9A12-9450-7051 | |
person.identifier.orcid | 0000-0001-9410-4772 | |
person.identifier.scopus-author-id | 57194785077 | |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
relation.isAuthorOfPublication | c0a8e5da-26ae-42a8-ab04-fa4df4356375 | |
relation.isAuthorOfPublication.latestForDiscovery | c0a8e5da-26ae-42a8-ab04-fa4df4356375 |
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