Publicação
Pretreatment antithrombotic strategies in non-ST elevation acute coronary syndromes in contemporaneous clinical practice
| datacite.subject.sdg | 04:Educação de Qualidade | |
| datacite.subject.sdg | 09:Indústria, Inovação e Infraestruturas | |
| datacite.subject.sdg | 15:Proteger a Vida Terrestre | |
| dc.contributor.author | Costa, Hugo | |
| dc.contributor.author | Espírito-Santo, Miguel | |
| dc.contributor.author | Fernandes, Raquel | |
| dc.contributor.author | Bispo, João | |
| dc.contributor.author | Guedes, João | |
| dc.contributor.author | Azevedo, Pedro | |
| dc.contributor.author | Carvalho Silva, Daniela | |
| dc.contributor.author | Vinhas, Hugo | |
| dc.contributor.author | Gonçalves, Rui Baptista | |
| dc.contributor.author | Mimoso, Jorge | |
| dc.date.accessioned | 2026-03-26T14:12:56Z | |
| dc.date.available | 2026-03-26T14:12:56Z | |
| dc.date.issued | 2024-11 | |
| dc.description.abstract | BACKGROUND Pretreatment antithrombotic strategies in non-ST elevation acute coronary syndromes (NSTE-ACS) during hospitalization is still a matter of contention within the cardiology community. Our aim was to analyze in-hospital and one-year follow-up outcomes of patients with NSTE-ACS pretreated with dual antiplatelet therapy (DAPT) versus single antiplatelet therapy (SAPT). METHODS A retrospective study was carried out with NSTE-ACS patients who planned to undergo an invasive strategy and were included in the Portuguese Registry of ACS between 2018 and 2021. A composite primary outcome (in-hospital re-infarction, stroke, heart failure, hemorrhage, death) was compared regarding antiplatelet strategy (DAPT versus SAPT). Secondary outcomes were defined as one-year all-cause mortality and one-year cardiovascular rehospitalization. RESULTS A total of 1469 patients were included, with a mean age of 66 12 years, and 73.9 % were male. The DAPT regime was used in 38.2 % of patients and SAPT in 61.8 % of patients. NSTE myocardial infarction was the most frequent presentation (88.5 %). Revascularization was performed within 24 h in 55.2% of patients. Time until revascularization >24 h occurred in 44.8% of patients, with 16.5% of these between [24 h–48 h], 10.6% in [48 h–72 h] and 17.6% > 72 h. The primary outcome was more frequently observed in the SAPT group (10.4 %, p ¼ 0.033), mainly driven by more ischemic events. Time until revascularization >72 h and the SAPT regime were independent predictors of the primary outcome (OR 3.09, p ¼ 0.005, and OR 2.03, p ¼ 0.008, respectively). | eng |
| dc.identifier.doi | 10.1016/j.hjc.2023.11.003 | |
| dc.identifier.issn | 1109-9666 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/28554 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Hellenic Journal of Cardiology | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Anticoagulation | |
| dc.subject | Antiplatelet strategy | |
| dc.subject | DAPT | |
| dc.subject | NSTE-ACS | |
| dc.subject | Pretreatment | |
| dc.subject | SAPT | |
| dc.title | Pretreatment antithrombotic strategies in non-ST elevation acute coronary syndromes in contemporaneous clinical practice | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 20 | |
| oaire.citation.startPage | 12 | |
| oaire.citation.title | Hellenic Journal of Cardiology | |
| oaire.citation.volume | 80 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Costa | |
| person.familyName | Fernandes | |
| person.familyName | Azevedo | |
| person.familyName | Carvalho Silva | |
| person.familyName | Mimoso | |
| person.givenName | Hugo | |
| person.givenName | Raquel | |
| person.givenName | Pedro | |
| person.givenName | Daniela | |
| person.givenName | Jorge | |
| person.identifier.orcid | 0000-0002-0670-6560 | |
| person.identifier.orcid | 0000-0002-2181-085X | |
| person.identifier.orcid | 0000-0002-1464-4785 | |
| person.identifier.orcid | 0000-0002-2730-6830 | |
| person.identifier.orcid | 0000-0002-2298-7892 | |
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