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Clear cell neoplasms of salivary glands: A diagnostic challenge

2022-07Journal article Restricted access
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dc.contributor.authorSkalova, Alena
dc.contributor.authorLeivo, Ilmo
dc.contributor.authorHellquist, Henrik
dc.contributor.authorSimpson, Roderick H.W.
dc.contributor.authorVander Poorten, Vincent
dc.contributor.authorWillems, Stefan M.
dc.contributor.authorMosaieby, Elaheh
dc.contributor.authorSlouka, David
dc.contributor.authorFerlito, Alfio
dc.date.accessioned2023-03-13T13:23:24Z
dc.date.available2023-03-13T13:23:24Z
dc.date.issued2022-07
dc.description.abstractThis review focuses on the heterogenous group of clear cell neoplasms of salivary glands and attempts to identify major differential diagnostic features. Within the head and neck region, clear cells are found most commonly in salivary gland tumors, but may also be seen in tumors of squamous or odontogenic epithelial origin, primary or metastatic carcinomas, benign or malignant melanocytic lesions, or benign or malignant mesenchymal tumors. Clear cells occur fairly commonly among a wide variety of salivary gland neoplasms, but mostly they constitute only a minor component of the tumor cell population. Clear cells represent a major diagnostic feature in two salivary gland neoplasms, epithelial-myoepithelial carcinoma and hyalinizing clear cell carcinoma. In addition, salivary gland neoplasms composed predominantly of clear cells could also include clear cell variants of other salivary neoplasms, such as mucoepidermoid carcinoma and myoepithelial carcinoma, but their tumor type-specific histologic features may only be available in limited nonclear cell areas of the tumor. Diagnosing predominantly clear cell salivary gland tumors is difficult because the immunoprofiles and morphologic features may overlap and the same tumor entity may also have a wide range of other histologic presentations. Many salivary gland tumors are characterized by tumor type-specific genomic alterations, particularly gene fusions of the ETV6 gene in secretory carcinoma, the MYB and MYBL1 genes in adenoid cystic carcinoma, the MAML2 gene in mucoepidermoid carcinoma, the EWSR1 gene in hyalinizing clear cell carcinoma, and others. Thus, along with conventional histopathologic examination and immunoprofiling, molecular and genetic tests may be important in the diagnosis of salivary gland clear cell tumors by demonstrating genetic alterations specific to them.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1097/PAP.0000000000000339pt_PT
dc.identifier.eissn1533-4031
dc.identifier.urihttp://hdl.handle.net/10400.1/19236
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott Williams & Wilkinspt_PT
dc.subjectClear cell neoplasmpt_PT
dc.subjectSalivary glandpt_PT
dc.subjectHyalinizing clear cell carcinomapt_PT
dc.subjectEpithelial-myoepithelial carcinomapt_PT
dc.subjectMetastatic clear cell carcinomapt_PT
dc.subjectOdontogenicpt_PT
dc.titleClear cell neoplasms of salivary glands: A diagnostic challengept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage226pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage217pt_PT
oaire.citation.titleAdvances in Anatomic Pathologypt_PT
oaire.citation.volume29pt_PT
person.familyNameHellquist
person.givenNameHenrik
person.identifier.ciencia-id9C11-221B-93BF
person.identifier.orcid0000-0003-3044-6065
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione632b82a-cf09-4f9a-b445-9d9a9de47438
relation.isAuthorOfPublication.latestForDiscoverye632b82a-cf09-4f9a-b445-9d9a9de47438

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