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Targeted Inactivation of Cerberus Like-2 Leads to Left Ventricular Cardiac Hyperplasia and Systolic Dysfunction in the Mouse

2014Journal article Open access
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dc.contributor.authorAraújo, Ana Carolina
dc.contributor.authorMarques, Sara
dc.contributor.authorBelo, José A.
dc.date.accessioned2018-12-07T14:53:08Z
dc.date.available2018-12-07T14:53:08Z
dc.date.issued2014
dc.description.abstractPrevious analysis of the Cerberus like 2 knockout (Cerl2(-/-)) mouse revealed a significant mortality during the first day after birth, mostly due to cardiac defects apparently associated with randomization of the left-right axis. We have however, identified Cerl2-associated cardiac defects, particularly a large increase in the left ventricular myocardial wall in neonates that cannot be explained by laterality abnormalities. Therefore, in order to access the endogenous role of Cerl2 in cardiogenesis, we analyzed the embryonic and neonatal hearts of Cerl2 null mutants that did not display a laterality phenotype. Neonatal mutants obtained from the compound mouse line Cer2(-/-)
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia (FCT); IBB/CBME [PEst-OE/EQB/LA0023/2011]; FCT [SFRH/BD/62081/2009]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1371/journal.pone.0102716
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.1/11366
dc.language.isoeng
dc.peerreviewedyes
dc.publisherPublic Library of Science
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCongenital heart-disease
dc.subjectCell-cycle regulation
dc.subjectEmbryonic stem-cells
dc.subjectEchocardiographic-assessment
dc.subjectTranscription factors
dc.subjectGene-expression
dc.subjectArterial pole
dc.subjectChick-embryo
dc.subjectField
dc.subjectCardiomyogenesis
dc.titleTargeted Inactivation of Cerberus Like-2 Leads to Left Ventricular Cardiac Hyperplasia and Systolic Dysfunction in the Mouse
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F62081%2F2009/PT
oaire.citation.issue7
oaire.citation.startPagee102716
oaire.citation.titlePLoS ONE
oaire.citation.volume9
oaire.fundingStreamSFRH
person.familyNameAraújo
person.familyNameMarques
person.familyNameBelo
person.givenNameAna Carolina
person.givenNameSara
person.givenNameJosé A.
person.identifier.ciencia-idBB17-0F5D-A4FB
person.identifier.ciencia-idBF13-08E9-25E6
person.identifier.orcid0000-0003-2599-1114
person.identifier.orcid0000-0001-6784-5612
person.identifier.orcid0000-0001-7384-0949
person.identifier.ridF-4444-2012
person.identifier.scopus-author-id6602141392
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication20dd7142-5b7a-465f-8943-a6ac33b91df1
relation.isAuthorOfPublication4bebeb48-6fac-41a9-8363-f849def5e019
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relation.isProjectOfPublication.latestForDiscovery34abaf5d-b5db-4539-a6bb-967708562f6d

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