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Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma: a collective international review

dc.contributor.authorHellquist, Henrik
dc.contributor.authorSkalova, Alena
dc.contributor.authorBarnes, Leon
dc.contributor.authorCardesa, Antonio
dc.contributor.authorThompson, Lester D. R.
dc.contributor.authorTriantafyllou, Asterios
dc.contributor.authorWilliams, Michelle D.
dc.contributor.authorDevaney, Kenneth O.
dc.contributor.authorGnepp, Douglas R.
dc.contributor.authorBishop, Justin A.
dc.contributor.authorWenig, Bruce M.
dc.contributor.authorSuarez, Carlos
dc.contributor.authorRodrigo, Juan P.
dc.contributor.authorCoca-Pelaz, Andres
dc.contributor.authorStrojan, Primoz
dc.contributor.authorShah, Jatin P.
dc.contributor.authorHamoir, Marc
dc.contributor.authorBradley, Patrick J.
dc.contributor.authorSilver, Carl E.
dc.contributor.authorSlootweg, Pieter J.
dc.contributor.authorVander Poorten, Vincent
dc.contributor.authorTeymoortash, Afshin
dc.contributor.authorMedina, Jesus E.
dc.contributor.authorRobbins, K. Thomas
dc.contributor.authorPitman, Karen T.
dc.contributor.authorKowalski, Luiz P.
dc.contributor.authorde Bree, Remco
dc.contributor.authorMendenhall, William M.
dc.contributor.authorEloy, Jean Anderson
dc.contributor.authorTakes, Robert P.
dc.contributor.authorRinaldo, Alessandra
dc.contributor.authorFerlito, Alfio
dc.date.accessioned2017-04-07T15:57:00Z
dc.date.available2017-04-07T15:57:00Z
dc.date.issued2016-07
dc.description.abstractAdenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.
dc.identifier.doi10.1007/s12325-016-0298-5
dc.identifier.issn0741-238X
dc.identifier.urihttp://hdl.handle.net/10400.1/9584
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Verlag
dc.relation.isbasedonWOS:000374258600004
dc.titleCervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma: a collective international review
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage368
oaire.citation.issue3
oaire.citation.startPage357
oaire.citation.titleAdvances in Therapy
oaire.citation.volume33
person.familyNameHellquist
person.givenNameHenrik
person.identifier.ciencia-id9C11-221B-93BF
person.identifier.orcid0000-0003-3044-6065
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicatione632b82a-cf09-4f9a-b445-9d9a9de47438
relation.isAuthorOfPublication.latestForDiscoverye632b82a-cf09-4f9a-b445-9d9a9de47438

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