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Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development

2016-04Journal article Open Access
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dc.contributor.authorFernandes, Mónica T.
dc.contributor.authorDejardin, Emmanuel
dc.contributor.authorRodrigues Dos Santos, Nuno
dc.date.accessioned2017-04-07T15:56:48Z
dc.date.available2017-04-07T15:56:48Z
dc.date.issued2016-04
dc.description.abstractThe LT alpha(1)beta(2) and LIGHT TNF superfamily cytokines exert pleiotropic physiological functions through the activation of their cognate lymphotoxin-beta receptor (LT beta R). Interestingly, since the discovery of these proteins, accumulating evidence has pinpointed a role for LT beta R signaling in carcinogenesis. Early studies have shown a potential anti-tumoral role in a subset of solid cancers either by triggering apoptosis in malignant cells or by eliciting an anti-tumor immune response. However, more recent studies provided robust evidence that LT beta R signaling is also involved in diverse cell-intrinsic and microenvironment-dependent pro-oncogenic mechanisms, affecting several solid and hematological malignancies. Consequently, the usefulness of LT beta R signaling axis blockade has been investigated as a potential therapeutic approach for cancer. Considering the seemingly opposite roles of LT beta R signaling in diverse cancer types and their key implications for therapy, we here extensively review the different mechanisms by which LT beta R activation affects carcinogenesis, focusing on the diverse contexts and different models assessed. (C) 2016 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.bbcan.2016.02.005
dc.identifier.issn0304-419X
dc.identifier.otherAUT: NRS02238;
dc.identifier.urihttp://hdl.handle.net/10400.1/9527
dc.language.isoeng
dc.peerreviewedyes
dc.relationINFLUENCE OF THYMIC STROMAL CELLS AND CHEMOKINE SIGNALING IN ACUTE T-CELL LEUKEMIA DEVELOPMENT
dc.relationLYMPHOTOXIN-BETA RECEPTOR AND RANK SIGNALING IN TEL-JAK2-INDUCED T-CELL LEUKEMIA
dc.relation.isbasedonWOS:000376546200012
dc.titleContext-dependent roles for lymphotoxin-beta receptor signaling in cancer development
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleINFLUENCE OF THYMIC STROMAL CELLS AND CHEMOKINE SIGNALING IN ACUTE T-CELL LEUKEMIA DEVELOPMENT
oaire.awardTitleLYMPHOTOXIN-BETA RECEPTOR AND RANK SIGNALING IN TEL-JAK2-INDUCED T-CELL LEUKEMIA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OBD%2F103336%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0023%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F75137%2F2010/PT
oaire.citation.endPage219
oaire.citation.issue2
oaire.citation.startPage204
oaire.citation.titleBiochimica et Biophysica Acta (BBA) - Reviews on Cancer
oaire.citation.volume1865
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameRodrigues dos Santos
person.givenNameNuno
person.identifier.orcid0000-0001-7347-2592
person.identifier.scopus-author-id7006810054
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscoverycd54e8ca-80e4-49d1-8fa1-d275fc51ddb2
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