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Epidemiological and clinical aspects of Cutaneous and Mucosal Leishmaniases in Portugal: retrospective analysis of cases diagnosed in public hospitals and reported in the literature between 2010 and 2020

2024-04-18Journal article Open access
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dc.contributor.authorRocha, Rafael
dc.contributor.authorConceição, Cláudia
dc.contributor.authorGonçalves, Luzia
dc.contributor.authorCarvalho, Ana Cláudia
dc.contributor.authorMaia, André
dc.contributor.authorMartins, André
dc.contributor.authorCarujo, António
dc.contributor.authorMaio, António
dc.contributor.authorForra, Catarina
dc.contributor.authorMelita, Catarina
dc.contributor.authorCouto, Daniela
dc.contributor.authorFernandes, Diana
dc.contributor.authorPereira, Dulce
dc.contributor.authorLeal, Ema
dc.contributor.authorSarmento, Helena
dc.contributor.authorSousa, Inês
dc.contributor.authorGonçalves, Jean-Pierre
dc.contributor.authorMarinho, Joana
dc.contributor.authorVasconcelos, Joana
dc.contributor.authorCunha, João
dc.contributor.authorRodrigues, João
dc.contributor.authorSilva, José Miguel
dc.contributor.authorCaley, Lídia
dc.contributor.authorMalheiro, Luís
dc.contributor.authorSantos, Luís
dc.contributor.authorGarcia, Margarida
dc.contributor.authorCunha, Maria
dc.contributor.authorLima, Maria
dc.contributor.authorAndrade, Maria Margarida
dc.contributor.authorMarques, Marta
dc.contributor.authorAlpalhão, Miguel
dc.contributor.authorSilva, Mónica
dc.contributor.authorFerraz, Rita
dc.contributor.authorSoares, Rui
dc.contributor.authorFernandes, Salomão
dc.contributor.authorLlobet, Samuel
dc.contributor.authorCruz, Sofia
dc.contributor.authorGuimarães, Teresa
dc.contributor.authorBranco, Tiago
dc.contributor.authorNunes, Tomás Robalo
dc.contributor.authorAlmeida, Vasco
dc.contributor.authorMaia, Carla
dc.date.accessioned2024-12-17T11:50:12Z
dc.date.available2024-12-17T11:50:12Z
dc.date.issued2024-04-18
dc.description.abstractLeishmania infantum, a zoonotic vector-born parasite, is endemic in the Mediterranean region, presenting mostly as visceral (VL), but also as cutaneous (CL) and mucosal leishmaniasis (ML). This study aimed to describe the epidemiological and clinical aspects of the CL and ML cases diagnosed in mainland Portugal between 2010 and 2020. Collaboration was requested from every hospital of the Portuguese National Health System. Cases were screened through a search of diagnostic discharge codes or positive laboratory results for Leishmania infection. Simultaneously, a comprehensive literature search was performed. Descriptive statistics and hypothesis testing were performed using IBM (R) SPSS (R) Statistics. A total of 43 CL and 7 ML cases were identified, with a predominance of autochthonous cases (86%). In CL, immunosuppressed individuals constituted a significant proportion of patients (48%), and in this group, disseminated CL (22%) and simultaneous VL (54%) were common. In autochthonous cases, lesions, mostly papules/nodules (62%), were frequently observed on the head (48%). The approach to treatment was very heterogeneous. ML cases were all autochthonous, were diagnosed primarily in older immunosuppressed individuals, and were generally treated with liposomal amphotericin B. The findings suggest a need for enhanced surveillance and reporting, clinical awareness, and diagnostic capacity of these forms of leishmaniasis to mitigate underdiagnosis and improve patient outcomes. A holistic One Health approach is advocated to address the multifaceted challenges posed by leishmaniases in Portugal and beyond.eng
dc.description.sponsorshipUI/BD/151067/2021); UID/Multi/04413/2020
dc.identifier.doi10.3390/microorganisms12040819
dc.identifier.issn2076-2607
dc.identifier.urihttp://hdl.handle.net/10400.1/26497
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCentre of Statistics and its Applications
dc.relationTranslation and Innovation towards Global Health
dc.relation.hasversionhttps://www.mdpi.com/2076-2607/12/4/819
dc.relation.ispartofMicroorganisms
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject2010–2020
dc.subjectLeishmania
dc.subjectPortugal
dc.subjectCutaneous
dc.subjectLeishmaniasis
dc.subjectMucosal
dc.titleEpidemiological and clinical aspects of Cutaneous and Mucosal Leishmaniases in Portugal: retrospective analysis of cases diagnosed in public hospitals and reported in the literature between 2010 and 2020eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardTitleTranslation and Innovation towards Global Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0117%2F2020/PT
oaire.citation.issue4
oaire.citation.startPage819
oaire.citation.titleMicroorganisms
oaire.citation.volume12
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication100e6d17-2f76-4282-b864-d0f887b34243
relation.isProjectOfPublication0774ac57-0b7c-4a2f-a6c1-aebbfba71c27
relation.isProjectOfPublication.latestForDiscovery100e6d17-2f76-4282-b864-d0f887b34243

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