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Adaptive mechanisms of resistance to antineoplastic agents

2017-01Journal article Restricted access
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dc.contributor.authorFerreira, Bibiana
dc.contributor.authorLie, Maria K.
dc.contributor.authorEngelsen, Agnete S. T.
dc.contributor.authorMachado, Susana
dc.contributor.authorLink, Wolfgang
dc.contributor.authorLorens, James B.
dc.date.accessioned2019-11-20T15:08:05Z
dc.date.available2019-11-20T15:08:05Z
dc.date.issued2017-01
dc.description.abstractIntrinsic and acquired resistance to conventional and targeted therapeutics is a fundamental reason for treatment failure in many cancer patients. Targeted approaches to overcome chemoresistance as well as resistance to targeted approaches require in depth understanding of the underlying molecular mechanisms. The anti-cancer activity of a drug can be limited by a broad variety of molecular events at different levels of drug action in a cell-autonomous and non-cell-autonomous manner. This review summarizes recent insights into the adaptive mechanisms used by tumours to resist therapy including cellular phenotypic plasticity, dynamic alterations of the tumour microenvironment, activation of redundant signal transduction pathways, modulation of drug target expression levels, and exploitation of pro-survival responses.
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia (FCT) [SFRH/BPD/100434/2014]
dc.description.sponsorshipResearch Center Grant Centre for Biomedical Research [UID/BIM/04773/2013, 1334]
dc.description.sponsorshipNorwegian Research Council
dc.description.sponsorshipNorwegian Cancer Society and Helse Vest Health Authority
dc.description.sponsorshipProRegem grant [PD/BD/114258/2016]
dc.description.versionInfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1039/c6md00394j
dc.identifier.issn2040-2503
dc.identifier.issn2040-2511
dc.identifier.urihttp://hdl.handle.net/10400.1/13354
dc.language.isoeng
dc.peerreviewedyes
dc.publisherRoyal Soc Chemistry
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTo-mesenchymal transition
dc.subjectReceptor tyrosine kinases
dc.subjectDna-damage response
dc.subjectBreast-cancer Cclls
dc.subjectAcute myelogenous leukemia
dc.subjectDrug-resistance
dc.subjectTumor microenvironment
dc.subjectMultidrug-resistance
dc.subjectOvarian-cancer
dc.subjectUp-Rrulation
dc.titleAdaptive mechanisms of resistance to antineoplastic agents
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.citation.endPage66
oaire.citation.issue1
oaire.citation.startPage53
oaire.citation.titleMedchemcomm
oaire.citation.volume8
oaire.fundingStream5876
person.familyNameferreira
person.familyNameMachado
person.familyNameLink
person.givenNameBibiana
person.givenNameSusana
person.givenNameWolfgang
person.identifier803637
person.identifier.ciencia-idA311-E925-09C5
person.identifier.ciencia-id6910-952E-242A
person.identifier.orcid0000-0003-4772-9395
person.identifier.orcid0000-0002-3152-1701
person.identifier.orcid0000-0002-3340-5165
person.identifier.ridK-4033-2012
person.identifier.scopus-author-id56201414700
person.identifier.scopus-author-id35368713800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication4972e808-7782-4cec-8d31-ab48a5899648
relation.isAuthorOfPublication12535e25-d71b-4a7f-9fc9-fff42d47deaf
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