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Altered serum levels of FGF-23 and magnesium are independent risk factors for an increased albumin-to-creatinine ratio in type 2 diabetics with chronic kidney disease

2016-07Journal article Restricted
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dc.contributor.authorSilva, Ana Paula
dc.contributor.authorMendes, Filipa
dc.contributor.authorFragoso, André
dc.contributor.authorJerĂłnimo, Teresa
dc.contributor.authorPimentel, Ana
dc.contributor.authorGundlach, Kristina
dc.contributor.authorBĂŒchel, Janine
dc.contributor.authorSantos, NĂ©lio
dc.contributor.authorNeves, Pedro LeĂŁo
dc.date.accessioned2017-04-07T15:57:03Z
dc.date.available2017-04-07T15:57:03Z
dc.date.issued2016-07
dc.description.abstractAims: To investigate the role of FGF-23 and magnesium in relation to the albumin-to-creatinine ratio in type 2 diabetics with chronic kidney disease (CKD) stages 2-4.Methods: In a cross-sectional study we included all eligible type 2 diabetic patients with CKD stages 2-4, followed in our outpatient Diabetic Kidney clinic. We used descriptive statistics, the Student's t-test, ANOVA and the chi-square tests. Our population was divided according to the UACR (G1 30-300 mg/g and G2 >= 300 mg/g), and compared these groups regarding several biological and laboratorial parameters. We employed a multiple regression model to identify risk factors of increased UACR.Results: The patients in G2 displayed a lower eGFR (p = 0.0001) and, had lower levels of magnesium (p = 0.004) as well as higher levels of FGF-23 (p = 0.043) compared to patients in Gl.FGF-23 (beta = 0.562, P = 0.0001) and the magnesium (beta = - 8.916, p = 0.0001) were associated with increased UACR.Conclusions: A dysregulation of mineral metabolism, reflected by altered levels of magnesium and FGF-23, correlates with an increased UACR in type 2 diabetic patients with CKD stages 2-4. (C) 2016 Elsevier Inc. All rights reserved.
dc.identifier.doihttps://doi.org/10.1016/j.jdiacomp.2015.11.006
dc.identifier.issn1056-8727
dc.identifier.otherAUT: PGS02043;
dc.identifier.urihttp://hdl.handle.net/10400.1/9598
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.isbasedonWOS:000371195100015
dc.subjectFGF-23
dc.subjectMagnesium
dc.subjectProteinuria
dc.subjectChronic kidney disease
dc.subjectDiabete
dc.titleAltered serum levels of FGF-23 and magnesium are independent risk factors for an increased albumin-to-creatinine ratio in type 2 diabetics with chronic kidney disease
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage280
oaire.citation.issue2
oaire.citation.startPage275
oaire.citation.titleJournal of Diabetes and its Complications
oaire.citation.volume30
person.familyNameMendes
person.familyNameNeves
person.givenNameFilipa
person.givenNamePedro LeĂŁo
person.identifier.ciencia-id1014-3EA2-C680
person.identifier.orcid0000-0002-0329-8805
person.identifier.orcid0000-0002-8463-0768
person.identifier.scopus-author-id7003907170
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication871b65e7-2325-4468-a518-070543f80346
relation.isAuthorOfPublication788c02e9-1087-4e30-8a34-5379261fc739
relation.isAuthorOfPublication.latestForDiscovery871b65e7-2325-4468-a518-070543f80346

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