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gga-miRNOME, a microRNA-sequencing dataset from chick embryonic tissues

2022Journal article Open Access
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dc.contributor.authorDuarte, Isabel
dc.contributor.authorCarraco, Gil
dc.contributor.authorde Azevedo, Nayara T. D.
dc.contributor.authorBenes, Vladimir
dc.contributor.authorAndrade, Raquel P.
dc.date.accessioned2022-07-21T08:28:45Z
dc.date.available2022-07-21T08:28:45Z
dc.date.issued2022
dc.description.abstractMicroRNAs (miRNAs) are small non-coding RNA molecules, with sizes ranging from 18 to 25 nucleotides, which are key players in gene expression regulation. These molecules play an important role in fine-tuning early vertebrate embryo development. However, there are scarce publicly available miRNA datasets from non-mammal embryos, such as the chicken (Gallus gallus), which is a classical model system to study vertebrate embryogenesis. Here, we performed microRNA-sequencing to characterize the early stages of trunk and limb development in the chick embryo. For this, we profiled three chick embryonic tissues, namely, Undetermined Presomitic Mesoderm (PSM_U), Determined Presomitic Mesoderm (PSM_D) and Forelimb Distal Cyclic Domain (DCD). We identified 926 known miRNAs, and 1,141 novel candidate miRNAs, which nearly duplicates the number of Gallus gallus entries in the miRBase database. These data will greatly benefit the avian research community, particularly by highlighting new miRNAs potentially involved in the regulation of early vertebrate embryo development, that can be prioritized for further experimental testing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41597-022-01126-7pt_PT
dc.identifier.eissn2052-4463
dc.identifier.urihttp://hdl.handle.net/10400.1/18050
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.relationTIMING CELL DIFFERENTIATON: Gene Regulatory Network in Temporal Control of Mesoderm Specification
dc.relationRegulating the pace of the Embryo Clock: RNA molecules in temporal control of vertebrate development
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectVertebrate segmentationpt_PT
dc.subjectOscillationspt_PT
dc.subjectExpressionpt_PT
dc.subjectDynamicspt_PT
dc.titlegga-miRNOME, a microRNA-sequencing dataset from chick embryonic tissuespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTIMING CELL DIFFERENTIATON: Gene Regulatory Network in Temporal Control of Mesoderm Specification
oaire.awardTitleRegulating the pace of the Embryo Clock: RNA molecules in temporal control of vertebrate development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BID%2F5410%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F101609%2F2014/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage29pt_PT
oaire.citation.titleScientific Datapt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamOE
person.familyNamedos Santos Duarte
person.familyNameCarraco
person.familyNameAndrade
person.givenNameGuilhermina Isabel
person.givenNameGil
person.givenNameRaquel
person.identifier.ciencia-idED15-7F67-7B64
person.identifier.ciencia-id2312-360B-227A
person.identifier.orcid0000-0003-0060-2936
person.identifier.orcid0000-0002-5008-6338
person.identifier.orcid0000-0002-0397-5917
person.identifier.scopus-author-id7103114918
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationb7311422-a085-4252-84fc-f8487296b474
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