Klotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients

Silva, Ana Paula; Mendes, Filipa; Pereira, Luisa; Fragoso, André; Baptista Gonçalves, Rui; Santos, Nelio; Rato, Fátima; Neves, Pedro Leão

Publication

Klotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients

2017-10Journal article

dc.contributor.author	Silva, Ana Paula
dc.contributor.author	Mendes, Filipa
dc.contributor.author	Pereira, Luisa
dc.contributor.author	Fragoso, André
dc.contributor.author	Baptista Gonçalves, Rui
dc.contributor.author	Santos, Nelio
dc.contributor.author	Rato, Fátima
dc.contributor.author	Neves, Pedro Leão
dc.date.accessioned	2019-11-20T15:07:19Z
dc.date.available	2019-11-20T15:07:19Z
dc.date.issued	2017-10
dc.description.abstract	The present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD. We conducted an observational, cross-sectional study in our outpatient diabetic nephropathy clinic from 2014 to 2016, enrolling a total of 107 type 2 diabetic patients with stage 2-3 CKD, with a mean age of 59 years. Several clinical and laboratorial parameters were evaluated, including those related to mineral and carbohydrate metabolism. The mean eGFR at baseline was 53.2 mL/min, and the mean levels of ACR and Klotho were 181.9 A mu g/mg and 331.1 pg/m, respectively. In the simple linear regression model, Klotho levels were correlated with age, phosphorus, PTH, ACR, HOMA, IL-6, FGF-23, OxLDL, eGFR and vitamin D levels. Applying a multivariate linear regression model, only the ACR, HOMA-IR, FGF-23 and vitamin D independently influenced the Klotho levels. In the generalized linear model, only the Klotho groups were statistically significant as independent variable (p = 0.007). The results show that the group 1 (< 268) compared with group 3 (> 440) had higher odds in the higher ACR (ae<yen>181), ORa = 3.429, p = 0.014. There were no statistically significant differences between Klotho groups 2 and 3, and the HOMA-IR obtained showed that group 1 (< 268) had greater odds of HOMA-IR ae<yen>2 when compared with group 3 (> 440), ORa = 21.59, p = 0.017. Our results showed that Klotho levels are influenced by FGF23, vitamin D and insulin resistance. This suggests that Klotho levels might be affected by renal function as well as having a relevant role on insulin metabolism and ACR homeostasis.
dc.description.version	info:eu-repo/semantics/publishedVersion
dc.identifier.doi	10.1007/s11255-017-1646-3
dc.identifier.issn	0301-1623
dc.identifier.issn	1573-2584
dc.identifier.uri	http://hdl.handle.net/10400.1/12980
dc.language.iso	eng
dc.peerreviewed	yes
dc.publisher	Springer
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Chronic kidney-disease
dc.subject	Serum Klotho
dc.subject	Phosphate
dc.subject	Glucose
dc.subject	Gene
dc.title	Klotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	1814
oaire.citation.issue	10
oaire.citation.startPage	1809
oaire.citation.title	International Urology and Nephrology
oaire.citation.volume	49
person.familyName	Mendes
person.familyName	Baptista Gonçalves
person.familyName	Neves
person.givenName	Filipa
person.givenName	Rui
person.givenName	Pedro Leão
person.identifier.ciencia-id	1014-3EA2-C680
person.identifier.orcid	0000-0002-0329-8805
person.identifier.orcid	0000-0002-4373-5379
person.identifier.orcid	0000-0002-8463-0768
person.identifier.scopus-author-id	7003907170
rcaap.rights	restrictedAccess
rcaap.type	article
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