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Tuberculosis Vaccines: an update of recent and ongoing clinical trials

2021-10Journal article Open access
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dc.contributor.authorSaramago, Sean
dc.contributor.authorMagalhães, Joana
dc.contributor.authorPinheiro, Marina
dc.date.accessioned2021-10-28T16:34:59Z
dc.date.available2021-10-28T16:34:59Z
dc.date.issued2021-10
dc.description.abstractTB remains a global health challenge and, until now, only one licensed vaccine (the BCG vaccine) is available. The main goal of this work is to assess the progress in the development of new TB vaccines and highlight the research in nanovaccines. A review was conducted using a methodology with the appropriate keywords and inclusion and exclusion criteria. The search revealed 37 clinical trials that were further reviewed. The results available have reported good immunogenicity and safety profiles for the vaccines under investigation. Over the last five years, the vaccines, VPM1002 and Vaccae, have moved ahead to phase III clinical trials, with the remaining candidate vaccines progressing in phase I and II clinical trials. RUTI and ID93+GLA-SE involve the use of nanoparticles. This strategy seems promising to improve the delivery, efficacy, cost, and storage conditions of the existing TB vaccines. In conclusion, the use of nanovaccines may be an option for both prevention and treatment. However, further studies are necessary for the development of novel TB vaccines.pt_PT
dc.description.sponsorshipPOCI-01-0145-FEDER-30624
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/app11199250pt_PT
dc.identifier.eissn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.1/17262
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationDL 57/2016pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectClinical trialspt_PT
dc.subjectInfectious diseasespt_PT
dc.subjectNanomedicinept_PT
dc.subjectPulmonary tuberculosispt_PT
dc.subjectTuberculosis preventionpt_PT
dc.titleTuberculosis Vaccines: an update of recent and ongoing clinical trialspt_PT
dc.title.alternativeVacinas contra tuberculose: uma atualização dos ensaios clínicos recentes e contínuospt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-MAT%2F30624%2F2017/PT
oaire.citation.issue19pt_PT
oaire.citation.startPage9250pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameSaramago
person.givenNameSean
person.identifier.orcid0000-0001-7702-8018
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryccceb840-9178-4b56-8d52-f36ccf7bfe35
relation.isProjectOfPublicationacdb6ead-bd66-4747-a102-8ec451f9913a
relation.isProjectOfPublication.latestForDiscoveryacdb6ead-bd66-4747-a102-8ec451f9913a

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