Neuroendocrine neoplasms of the sinonasal region

Bell, Diana; Hanna, Ehab Y.; Weber, Randal S.; DeMonte, Franco; Triantafyllou, Asterios; Lewis, James S., Jr.; Cardesa, Antonio; Slootweg, Pieter J.; Stenman, Goran; Gnepp, Douglas R.; Devaney, Kenneth O.; Rodrigo, Juan P.; Rinaldo, Alessandra; Wenig, Bruce M.; Westra, William H.; Bishop, Justin A.; Hellquist, Henrik; Hunt, Jennifer L.; Kusafuka, Kimihide; Perez-Ordonez, Bayardo; Williams, Michelle D.; Takes, Robert P.; Ferlito, Alfio

http://hdl.handle.net/10400.1/9537

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Autores

Triantafyllou, Asterios

Resumo(s)

Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined. (C) 2015 Wiley Periodicals, Inc.

URI

http://hdl.handle.net/10400.1/9537

Editora

Wiley

DOI

10.1002/hed.24152

Coleções

FCB2-Artigos (em revistas ou actas indexadas)

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