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Effectiveness and long-term retention of anti-tumour necrosis factor treatment in juvenile and adult patients with juvenile idiopathic arthritis: data from Reuma.pt

2016-04Journal article Open access
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dc.contributor.authorMourao, Ana F.
dc.contributor.authorSantos, Maria J.
dc.contributor.authorMelo Gomes, Jose A.
dc.contributor.authorMartins, Fernando M.
dc.contributor.authorMendonca, Silvia C.
dc.contributor.authorRamos, Filipa Oliveira
dc.contributor.authorFernandes, Susana
dc.contributor.authorSalgado, Manuel
dc.contributor.authorGuedes, Margarida
dc.contributor.authorCarvalho, Sonia
dc.contributor.authorCosta, Jose A.
dc.contributor.authorBrito, Iva
dc.contributor.authorDuarte, Catia
dc.contributor.authorFurtado, Carolina
dc.contributor.authorLopes, Ana
dc.contributor.authorRodrigues, Ana
dc.contributor.authorSequeira, Graca
dc.contributor.authorBranco, Jaime C.
dc.contributor.authorFonseca, Joao E.
dc.contributor.authorCanhao, Helena
dc.date.accessioned2017-04-07T15:56:49Z
dc.date.available2017-04-07T15:56:49Z
dc.date.issued2016-04
dc.description.abstractMethods. We prospectively collected patient and disease characteristics from patients with JIA who started biological therapy. Adverse events were collected during the follow-up period. Predictors of response at 1 year and drug retention rates were assessed at 4 years of treatment for the first biologic agent.Results. A total of 812 JIA patients [65% females, mean age at JIA onset 6.9 years (s.d. 4.7)], 227 received biologic therapy; 205 patients (90.3%) were treated with an anti-TNF as the first biologic. All the parameters used to evaluate disease activity, namely number of active joints, ESR and Childhood HAQ/HAQ, decreased significantly at 6 months and 1 year of treatment. The mean reduction in Juvenile Disease Activity Score 10 (JADAS10) after 1 year of treatment was 10.4 (s.d. 7.4). According to the definition of improvement using the JADAS10 score, 83.3% respond to biologic therapy after 1 year. Fourteen patients discontinued biologic therapies due to adverse events. Retention rates were 92.9% at 1 year, 85.5% at 2 years, 78.4% at 3 years and 68.1% at 4 years of treatment. Among all JIA subtypes, only concomitant therapy with corticosteroids was found to be univariately associated with withdrawal of biologic treatment (P = 0.016).Conclusion. Biologic therapies seem effective and safe in patients with JIA. In addition, the retention rates for the first biologic agent are high throughout 4 years.
dc.identifier.doi10.1093/rheumatology/kev398
dc.identifier.issn1462-0324
dc.identifier.urihttp://hdl.handle.net/10400.1/9533
dc.language.isoeng
dc.peerreviewedyes
dc.relation.isbasedonWOS:000374234100015
dc.titleEffectiveness and long-term retention of anti-tumour necrosis factor treatment in juvenile and adult patients with juvenile idiopathic arthritis: data from Reuma.pt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage703
oaire.citation.issue4
oaire.citation.startPage697
oaire.citation.titleRHEUMATOLOGY
oaire.citation.volume55
rcaap.rightsopenAccess
rcaap.typearticle

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