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Predictors of myositis in mixed connective tissue disease: a multicentre retrospective study

2024-09-30Journal article Open Access
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dc.contributor.authorMelo, A. T.
dc.contributor.authorAntónio, M. Silvério
dc.contributor.authorMartinho, J. Martins
dc.contributor.authorGuimarães, F.
dc.contributor.authorDourado, E.
dc.contributor.authorOliveira, D.
dc.contributor.authorLopes, J.
dc.contributor.authorSaraiva, A.
dc.contributor.authorGago, A.
dc.contributor.authorCorreia, M.
dc.contributor.authorFernandes, A. L.
dc.contributor.authorDinis, S.
dc.contributor.authorTeixeira, R.
dc.contributor.authorSilva, S. P.
dc.contributor.authorCosta, C.
dc.contributor.authorBeirão, T.
dc.contributor.authorFurtado, C.
dc.contributor.authorAbreu, P.
dc.contributor.authorKhmelinskii, N.
dc.date.accessioned2024-12-19T12:57:55Z
dc.date.available2024-12-19T12:57:55Z
dc.date.issued2024-09-30
dc.description.abstractObjectives: We aimed to identify clinical and serological predictors of myositis in mixed connective tissue disease (MCTD). Methods: We performed a nationwide, retrospective, multicentre study including adult-onset MCTD patients fulfilling at least one of the following diagnostic criteria: Sharp’s, Kasukawa, Alarcón-Segovia, or Kahn’s. Univariable analysis was performed using Chi-square, Fisher exact, Student’s t or Mann-Whitney U tests, as appropriate. Multivariable analysis was performed using binary logistic regression. Results: Ninety-eight patients were included. Myositis was observed in 43.9% of patients, of whom 60.5% had myositis at disease onset. Proximal muscle weakness was described in 30 patients with muscle involvement (70%). Gastrointestinal involvement was identified in 28% and respiratory involvement in 29% of myositis patients. In the same subgroup of patients, 41.7% had a myopathic pattern on electromyography, and 47.1% had histological myositis features in the muscle biopsy. Fever (OR=6.96, p=0.022) was an independent predictor of myositis, regardless of sex, age at diagnosis, ancestry, and respiratory involvement. African ancestry (OR=8.39, p=0.019), leukopenia at the disease onset (OR 6.24, p=0.021), and younger age at diagnosis (OR=1.07/year, p=0.035) were identified as independent predictors of myositis at disease onset, regardless of sex and scleroderma pattern in capillaroscopy. Conclusions: Myositis is a common manifestation of MCTD, even at the disease onset. African ancestry, leukopenia at the disease onset, younger age at diagnosis, and fever should prompt a thorough evaluation for myositis.eng
dc.identifier.doi10.63032/bayu2491
dc.identifier.eissn2795-4552
dc.identifier.issn2795-4552
dc.identifier.urihttp://hdl.handle.net/10400.1/26516
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSociedade Portuguesa de Reumatologia
dc.relation.ispartofARP Rheumatology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMixed connective tissue disease
dc.subjectMyositis
dc.subjectPredictors
dc.titlePredictors of myositis in mixed connective tissue disease: a multicentre retrospective studyeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage181
oaire.citation.issue3
oaire.citation.startPage174
oaire.citation.titleARP Rheumatology
oaire.citation.volume3
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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