Repository logo
 
Publication

Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling

2016-08Journal article Open Access
Simple item page
dc.contributor.authorNavarro-Costa, Paulo
dc.contributor.authorMcCarthy, Alicia
dc.contributor.authorPrudencio, Pedro
dc.contributor.authorGreer, Christina
dc.contributor.authorGuilgur, Leonardo Gastón
dc.contributor.authorBecker, Jorg D.
dc.contributor.authorSecombe, Julie
dc.contributor.authorRangan, Prashanth
dc.contributor.authorMartinho, Rui Goncalo
dc.date.accessioned2017-04-07T15:56:17Z
dc.date.available2017-04-07T15:56:17Z
dc.date.issued2016-08
dc.description.abstractOocytes are arrested for long periods of time in the prophase of the first meiotic division (prophase I). As chromosome condensation poses significant constraints to gene expression, the mechanisms regulating transcriptional activity in the prophase I-arrested oocyte are still not entirely understood. We hypothesized that gene expression during the prophase I arrest is primarily epigenetically regulated. Here we comprehensively define the Drosophila female germ line epigenome throughout oogenesis and show that the oocyte has a unique, dynamic and remarkably diversified epigenome characterized by the presence of both euchromatic and heterochromatic marks. We observed that the perturbation of the oocyte's epigenome in early oogenesis, through depletion of the dKDM5 histone demethylase, results in the temporal deregulation of meiotic transcription and affects female fertility. Taken together, our results indicate that the early programming of the oocyte epigenome primes meiotic chromatin for subsequent functions in late prophase I.
dc.identifier.doi10.1038/ncomms12331
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/10400.1/9369
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Publishing Group
dc.relationProtein targeting and N-terminal acetylation
dc.relation.isbasedonWOS:000381524800001
dc.titleEarly programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleProtein targeting and N-terminal acetylation
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-BQB%2F0712%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.citation.endPage12331
oaire.citation.startPage12331
oaire.citation.titleNature Communications
oaire.citation.volume7
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameNavarro-Costa
person.familyNamePrudêncio
person.familyNameGuilgur
person.familyNameViegas Russo da Conceição Martinho
person.givenNamePaulo
person.givenNamePedro
person.givenNameLeonardo Gastón
person.givenNameRui Gonçalo
person.identifier770805
person.identifier.ciencia-id4A1A-BB74-58B7
person.identifier.ciencia-id7B1C-9F36-22C8
person.identifier.ciencia-idF31D-C783-3D89
person.identifier.orcid0000-0002-8543-4179
person.identifier.orcid0000-0003-1390-8491
person.identifier.orcid0000-0002-8197-5920
person.identifier.orcid0000-0002-1641-3403
person.identifier.scopus-author-id8370364000
person.identifier.scopus-author-id54884299400
person.identifier.scopus-author-id7801516140
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication41d72b7b-2494-494f-9953-2863f0dfbb66
relation.isAuthorOfPublication21b404fb-0e0d-483f-8322-49d71a15db06
relation.isAuthorOfPublication1b68412d-4044-440e-bea8-61f9c7d4c9da
relation.isAuthorOfPublication8891c3b2-0f45-4db4-8772-b1dadcf89585
relation.isAuthorOfPublication.latestForDiscovery21b404fb-0e0d-483f-8322-49d71a15db06
relation.isProjectOfPublication342c6bbb-8658-47b1-b792-90ff2cdd9f8e
relation.isProjectOfPublicatione13142f2-37b8-4b5a-b2cd-352e62003184
relation.isProjectOfPublication.latestForDiscovery342c6bbb-8658-47b1-b792-90ff2cdd9f8e

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
handle9369.pdf
Size:
3.12 MB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)