Repository logo
 
Publication

An overview of the spindle assembly checkpoint status in oral cancer

2014Journal article Open Access
Simple item page
dc.contributor.authorTeixeira, Jose Henrique
dc.contributor.authorSilva, Patrícia
dc.contributor.authorReis, Rita Margarida
dc.contributor.authorMoura, Ines Moranguinho
dc.contributor.authorMarques, Sandra
dc.contributor.authorFonseca, Joana
dc.contributor.authorMonteiro, Luis Silva
dc.contributor.authorBousbaa, Hassan
dc.date.accessioned2018-12-07T14:58:28Z
dc.date.available2018-12-07T14:58:28Z
dc.date.issued2014
dc.description.abstractAbnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer. Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy. In normal cells, SAC prevents anaphase onset until all chromosomes are correctly aligned at the metaphase plate thereby ensuring genomic stability. Significantly, the activity of this checkpoint is compromised in many cancers. While mutations are rather rare, many tumors show altered expression levels of SAC components. Genomic alterations such as aneuploidy indicate a high risk of oral cancer and cancer-related mortality, and the molecular basis of these alterations is largely unknown. Yet, our knowledge on the status of SAC components in oral cancer remains sparse. In this review, we address the state of our knowledge regarding the SAC defects and the underlying molecular mechanisms in oral cancer, and discuss their therapeutic relevance, focusing our analysis on the core components of SAC and its target Cdc20.
dc.description.sponsorshipCESPU [02-GCQF-CICS-2011N, 01-GCD-CICS-09; 02-GCD-CICS-09, 05-GCD-CICS-2011]; Fundacao para a Ciencia e a Tecnologia (FCT) [CEQUIMED-PEst-OE/SAU/UI4040/2011];
dc.identifier.doi10.1155/2014/145289
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.urihttp://hdl.handle.net/10400.1/12041
dc.language.isoeng
dc.peerreviewedyes
dc.publisherHindawi Publishing Corporation
dc.subjectSquamous-cell carcinoma
dc.subjectAurora-B expression
dc.subjectMitotic checkpoint
dc.subjectChromosomal instability
dc.subjectCenp-E
dc.subjectKinetochore localization
dc.subjectMolecular pathogenesis
dc.subjectHuman-papillomavirus
dc.subjectTumor-suppressor
dc.subjectBubr1
dc.titleAn overview of the spindle assembly checkpoint status in oral cancer
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F90744%2F2012/PT
oaire.citation.startPage145289
oaire.citation.titleBioMed Research International
oaire.fundingStreamSFRH
person.familyNameSilva
person.givenNamePatrícia
person.identifier1445798
person.identifier.ciencia-id4B19-7E26-A047
person.identifier.orcid0000-0002-0694-7321
person.identifier.scopus-author-id55855611900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationc2baf55d-94d7-4d71-b9f6-307d37cd4685
relation.isAuthorOfPublication.latestForDiscoveryc2baf55d-94d7-4d71-b9f6-307d37cd4685
relation.isProjectOfPublicationeec7a7cf-4fd5-403f-b70a-cb2d401e1558
relation.isProjectOfPublication.latestForDiscoveryeec7a7cf-4fd5-403f-b70a-cb2d401e1558

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
12041.pdf
Size:
1.57 MB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)