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A systematic review of bleomycin-induced gonadotoxicity: Mechanistic implications for male reproductive health and fertility

2024-12Journal article Open access
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dc.contributor.authorAlmeida, Ana Lobo de
dc.contributor.authorFortuna, Ana
dc.contributor.authorSousa, Mário
dc.contributor.authorSá, Rosália
dc.date.accessioned2024-12-06T11:51:45Z
dc.date.available2024-12-06T11:51:45Z
dc.date.issued2024-12
dc.description.abstractLong-term cancer treatment complications in men include testicular dysfunction and infertility. Although various chemotherapies have been studied, there is limited evidence on their effects, especially for bleomycin. Despite its known lung toxicity, bleomycin's impact on male reproductive health is not well-researched. This systematic review aimed to evaluate bleomycin's effects on testicular function and fertility. A search of PubMed and Web of Science identified seven relevant animal studies on bleomycin's gonadotoxicity. The research, limited to animal models, shows that bleomycin significantly disrupts male reproductive health, including DNA damage in sperm, analogous to its effects on cancer cells, and notable histopathological changes in rodent testes. It reduces sperm quality and testosterone levels, correlating with Leydig cell degeneration and inflammatory responses, which further aligns with the drug's known capacity to induce lung inflammation. Due to the inherent limitations in extrapolating results from rodents to humans, further research, particularly in humans, is needed to confirm these findings, assess hormonal impacts, temporal patterns of effects (whether transient or permanent), and their impacts implications for offspring, as well explore potential mitigation strategies. These findings are a first step in raising awareness among clinicians about bleomycin's fertility risks and developing strategies for fertility preservation.eng
dc.identifier.doi10.1016/j.reprotox.2024.108721
dc.identifier.issn0890-6238
dc.identifier.urihttp://hdl.handle.net/10400.1/26411
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationUnit for Multidisciplinary Research in Biomedicine
dc.relationUnit for Multidisciplinary Research in Biomedicine
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0890623824001886?via%3Dihub
dc.relation.ispartofReproductive Toxicology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAnimal studies
dc.subjectBleomycin
dc.subjectChemotherapy
dc.subjectMale fertility
dc.subjectReproductive toxicity
dc.subjectTesticular function
dc.titleA systematic review of bleomycin-induced gonadotoxicity: Mechanistic implications for male reproductive health and fertilityeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUnit for Multidisciplinary Research in Biomedicine
oaire.awardTitleUnit for Multidisciplinary Research in Biomedicine
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00215%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00215%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.endPage10
oaire.citation.startPage1
oaire.citation.titleReproductive Toxicology
oaire.citation.volume130
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication23f88acf-6c29-4c4d-9321-9d0a491e644f
relation.isProjectOfPublication5da0b1ac-b581-419c-b074-65ec5e8ba043
relation.isProjectOfPublication69749040-5262-485a-a499-40fbd4d87651
relation.isProjectOfPublication.latestForDiscovery23f88acf-6c29-4c4d-9321-9d0a491e644f

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