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Long COVID-19 fatigue and obstructive sleep apnea: is there a relation?

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Fatigue has been reported as the most frequent long COVID-19 symptom. There is a physiological plausibility for relation be tween OSA and long-COVID-19 fatigue, by Intermittent nocturnal hypox emia, endothelial dysfunction, oxidative stress and low grade systemic inflammation. OSA activates the renin-angiotensin-aldosterone system (RAAS) and angiotensin-converting enzyme 2 (ACE2), which is the entry receptor for SARS-CoV-2. The aim of this study is to evaluate if untreated OSA is associated with COVID-19 long-term fatigue.

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Elsevier

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