Repository logo
 
Publication

Non-viral strategies for ocular gene delivery

2017-08Journal article Restricted access
Simple item page
dc.contributor.authorV. Oliveira, Ana
dc.contributor.authorRosa Da Costa, Ana
dc.contributor.authorSilva, Gabriela A.
dc.date.accessioned2019-11-20T15:07:29Z
dc.date.available2019-11-20T15:07:29Z
dc.date.issued2017-08
dc.description.abstractThe success of gene therapy relies on efficient gene transfer and stable transgene expression. The in vivo efficiency is determined by the delivery vector, route of administration, therapeutic gene, and target cells. While some requirements are common to several strategies, others depend on the target disease and transgene product. Consequently, it is unlikely that a single system is suitable for all applications. This review examines current gene therapy strategies, focusing on non-viral approaches and the use of natural polymers with the eye, and particularly the retina, as their gene delivery target. (C) 2017 Elsevier B.V. All rights reserved.
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia [PTDC/SAU-BEB/098475/2008, SFRH/BD/70318/2010, PEst-OE/EQB/LA0023/2013, PEst-OE_QUI_UI4023_2011]
dc.description.sponsorshipiNOVA4Health Research Unit [LISBOA-01-0145-FEDER-007344]
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia / Ministerio da Ciencia ado Ensino Superior
dc.description.sponsorshipFEDER
dc.description.sponsorshipMarie Curie Reintegration Grant under the FP7 program [PIRG-GA-2009-249314]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.msec.2017.04.068
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.urihttp://hdl.handle.net/10400.1/13060
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationDEVELOPMENT OF NON-VIRAL VECTORS FOR GENE THERAPY FOR PATHOLOGIES OF THE RETINA
dc.subjectRetinal-pigment epithelium
dc.subjectHyaluronic-acid
dc.subjectIn-vivo
dc.subjectBiomedical applications
dc.subjectPlasmid Dna
dc.subjectChitosan nanoparticles
dc.subjectDrug-delivery
dc.subjectTransfection efficiency
dc.subjectMagnetic nanoparticles
dc.subjectNeurotrophic factor
dc.titleNon-viral strategies for ocular gene delivery
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDEVELOPMENT OF NON-VIRAL VECTORS FOR GENE THERAPY FOR PATHOLOGIES OF THE RETINA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-BEB%2F098475%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70318%2F2010/PT
oaire.citation.endPage1289
oaire.citation.startPage1275
oaire.citation.titleMaterials Science & Engineering C-Materials For Biological Applications
oaire.citation.volume77
oaire.fundingStream3599-PPCDT
person.familyNameOliveira
person.familyNameRosa da Costa
person.givenNameAna
person.givenNameAna M
person.identifier305029
person.identifier.ciencia-idCA17-42CB-F11B
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.orcid0000-0003-3162-250X
person.identifier.orcid0000-0003-0225-9537
person.identifier.ridE-2165-2012
person.identifier.scopus-author-id55989431200
person.identifier.scopus-author-id53986075100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicatione5eea0c7-acf8-4bfe-932c-58d770b144bd
relation.isAuthorOfPublication0ca8c16f-6881-4662-bafc-cc51c5ce8d88
relation.isAuthorOfPublication.latestForDiscoverye5eea0c7-acf8-4bfe-932c-58d770b144bd
relation.isProjectOfPublication610cf07c-9c35-43ca-933b-27e8122a5fcd
relation.isProjectOfPublicationea46c108-e292-4eb0-abb6-39add8a55215
relation.isProjectOfPublication.latestForDiscovery610cf07c-9c35-43ca-933b-27e8122a5fcd

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
1-s2.0-S0928493117309827-main.pdf
Size:
1013.97 KB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)