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Sinonasal undifferentiated carcinoma (SNUC): from an entity to morphologic pattern and back again-a historical perspective

2020-03Journal article Restricted
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dc.contributor.authorAgaimy, Abbas
dc.contributor.authorFranchi, Alessandro
dc.contributor.authorLund, Valerie J.
dc.contributor.authorSkalova, Alena
dc.contributor.authorBishop, Justin A.
dc.contributor.authorTriantafyllou, Asterios
dc.contributor.authorAndreasen, Simon
dc.contributor.authorGnepp, Douglas R.
dc.contributor.authorHellquist, Henrik
dc.contributor.authorThompson, Lester D. R.
dc.contributor.authorRinaldo, Alessandra
dc.contributor.authorFerlito, Alfio
dc.date.accessioned2021-06-24T11:35:52Z
dc.date.available2021-06-24T11:35:52Z
dc.date.issued2020-03
dc.description.abstractSince the first description of sinonasal undifferentiated carcinoma (SNUC) as a distinctive highly aggressive sinonasal neoplasm with probable origin from the sinonasal mucosa (Schneiderian epithelium), SNUC has been the subject of ongoing study and controversy. In particular, the SNUC category gradually became a "wastebasket" for any undifferentiated or unclassifiable sinonasal malignancy of definite or probable epithelial origin. However, with the availability of more specific and sensitive immunohistochemical antibodies and increasing implementation of novel genetic tools, the historical SNUC category became the subject of progressive subdivision leading to recognition of specific genetically defined, reproducible subtypes. These recently recognized entities are characterized by distinctive genetic aberrations including NUTM1-rearranged carcinoma (NUT carcinoma) and carcinomas associated with inactivation of different members of the SWI/SNF chromatin-remodeling gene complex such as SMARCB1-deficient and less frequently SMARCA4-deficient carcinoma. The ring became almost closed, with recent studies highlighting frequent oncogenic IDH2 mutations in the vast majority of histologically defined SNUCs, with a frequency of 82%. A review of these cases suggests the possibility that "true SNUC" probably represents a distinctive neoplastic disease entity, morphologically, phenotypically, and genetically. This review addresses this topic from a historical perspective, with a focus on recently recognized genetically defined subsets within the SNUC spectrum.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1097/PAP.0000000000000258
dc.identifier.issn1072-4109
dc.identifier.urihttp://hdl.handle.net/10400.1/16557
dc.language.isoeng
dc.peerreviewedyes
dc.publisherLippincott, Williams & Wilkins
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSinonasal undifferentiated carcinoma
dc.subjectNUT carcinoma
dc.subjectSMARCB1-deficient carcinoma
dc.subjectSMARCA4-deficient carcinoma
dc.subjectOlfactory neuroblastoma
dc.subjectTeratocarcinosarcoma
dc.subjectIDH2
dc.subjectMutation
dc.subjectSMARCB1 protein
dc.subject.otherPathology
dc.titleSinonasal undifferentiated carcinoma (SNUC): from an entity to morphologic pattern and back again-a historical perspective
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage60
oaire.citation.issue2
oaire.citation.startPage51
oaire.citation.titleAdvances in Anatomic Pathology
oaire.citation.volume27
person.familyNameHellquist
person.givenNameHenrik
person.identifier.ciencia-id9C11-221B-93BF
person.identifier.orcid0000-0003-3044-6065
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicatione632b82a-cf09-4f9a-b445-9d9a9de47438
relation.isAuthorOfPublication.latestForDiscoverye632b82a-cf09-4f9a-b445-9d9a9de47438

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