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Spindle Assembly Checkpoint as a Potential Target in Colorectal Cancer: Current Status and Future Perspectives

2017-03Journal article Restricted
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dc.contributor.authorDiogo, Vania
dc.contributor.authorTeixeira, Joana
dc.contributor.authorSilva, Patrícia M.A.
dc.contributor.authorBousbaa, Hassan
dc.date.accessioned2019-11-20T15:07:46Z
dc.date.available2019-11-20T15:07:46Z
dc.date.issued2017-03
dc.description.abstractColorectal cancer (CRC), one of the most common malignancies worldwide, is often diagnosed at an advanced stage, and resistance to chemotherapeutic and existing targeted therapy is a major obstacle to its successful treatment. New targets that offer alternative clinical options are therefore urgently needed. Recently, perturbation of the spindle assembly checkpoint (SAC), the surveillance mechanism that maintains anaphase inhibition until all chromosomes reach the metaphase plate, has been regarded as a promising target to fight cancer cells, either alone or in combination regimens. Consistent with this strategy, many cancers, including CRC, exhibit altered expression of SAC genes. In this article, we review our current knowledge on SAC activity status in CRC, and on current anti-CRC strategies and future therapeutic perspectives on the basis of SAC targeting experiments in vitro and in animal models. (C) 2016 Elsevier Inc. All rights reserved.
dc.description.sponsorshipCESPU [02-GCQF-CICS-2011N, CheckTax-CESPU-2014]
dc.description.sponsorshipFoundation for Science and Technology (FCT)
dc.description.sponsorshipEuropean Regional Development Fund
dc.description.sponsorshipCOMPETE [PEst-C/MAR/LA0015/2013, PTDC/MAR-BIO/4694/2014]
dc.description.sponsorshipFCT [SFRH/BD/90744/2012]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.clcc.2016.06.006
dc.identifier.issn1533-0028
dc.identifier.issn1938-0674
dc.identifier.urihttp://hdl.handle.net/10400.1/13203
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCig Media Group, Lp
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectAurora kinase inhibitor
dc.subjectSmall-molecule inhibitor
dc.subjectPolo-like kinases
dc.subjectGrowth in-vivo
dc.subjectBroad antitumor-activity
dc.subjectAdvanced solid tumors
dc.subjectMitotic checkpoint
dc.subjectColon-cancer
dc.subjectChromosomal instability
dc.subjectPhase-I
dc.titleSpindle Assembly Checkpoint as a Potential Target in Colorectal Cancer: Current Status and Future Perspectives
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FMAR%2FLA0015%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F90744%2F2012/PT
oaire.citation.endPage8
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleClinical Colorectal Cancer
oaire.citation.volume16
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
person.familyNameSilva
person.givenNamePatrícia
person.identifier1445798
person.identifier.ciencia-id4B19-7E26-A047
person.identifier.orcid0000-0002-0694-7321
person.identifier.scopus-author-id55855611900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscoveryc2baf55d-94d7-4d71-b9f6-307d37cd4685
relation.isProjectOfPublication54af5688-34c3-4241-8c3e-ae96076831ff
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relation.isProjectOfPublication.latestForDiscovery54af5688-34c3-4241-8c3e-ae96076831ff

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