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New perspectives on the conservative management of osteoradionecrosis of the mandible: A literature review

2016-07Journal article Restricted
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dc.contributor.authorCosta, Diogo Alpuim
dc.contributor.authorCosta, Tiago Porfírio
dc.contributor.authorNetto, Eduardo Carlinhos
dc.contributor.authorJoaquim, Natércia
dc.contributor.authorVentura, Isabel
dc.contributor.authorPratas, Ana Cristina
dc.contributor.authorWinckler, Patricia
dc.contributor.authorSilva, Inês Pires
dc.contributor.authorPinho, Ana Catarina
dc.contributor.authorSargento, Isabel Goulão
dc.contributor.authorGuerreiro, Francisco Gamito
dc.contributor.authorMoreira, António Rita
dc.date.accessioned2017-04-07T15:55:48Z
dc.date.available2017-04-07T15:55:48Z
dc.date.issued2016-07
dc.description.abstractOver the last decades, several therapeutic options were considered in the treatment of the osteoradionecrosis (ORN) of the mandible, including supportive measures, ultrasound therapy, corticosteroids, hyperbaric oxygen, surgical resection with reconstruction, and, more recently, drugs capable of reversing the fibroatrophic process. Once established, the ORN does not spontaneously disappear and a standard treatment has not yet been defined. The clear clinical effectiveness of hyperbaric oxygen therapy (HBOT) varies according to the literature and there are some economic/logistic issues to be considered; the triplet tocopherol/pentoxifylline/clodronate demands greater evidence from randomized clinical trials and also resilience from the patient, given the long treatment duration and its possible side effects. Controversy around the ideal treatment of the initial stage ORN of the mandible persists. More rigorous randomized prospective trials are essential. The purpose of this article was to review the relevant literature on the physiopathology of ORN of the mandible and discuss the new perspectives of its conservative treatment. (C) 2016 Wiley Periodicals, Inc.
dc.identifier.doi10.1002/hed.24495
dc.identifier.issn1043-3074
dc.identifier.urihttp://hdl.handle.net/10400.1/9222
dc.language.isoeng
dc.peerreviewedyes
dc.relation.isbasedonWOS:000388367200019
dc.titleNew perspectives on the conservative management of osteoradionecrosis of the mandible: A literature review
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1716
oaire.citation.issue11
oaire.citation.startPage1708
oaire.citation.titleHead & Neck : Journal for the Sciences and Specialitiesof the Head and Neck
oaire.citation.volume38
person.familyNameJoaquim
person.givenNameNatércia
person.identifier.ciencia-idFF15-DF5C-F320
person.identifier.orcid0000-0003-1567-0157
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication57e6b735-ffff-4589-b522-d38fce2e15c2
relation.isAuthorOfPublication.latestForDiscovery57e6b735-ffff-4589-b522-d38fce2e15c2

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