Repository logo
 
Publication

Extracellular proteins: Novel Key components of metal resistance in cyanobacteria?

2016-06Journal article Open access
Simple item page
dc.contributor.authorJoaquín, Giner-Lamia
dc.contributor.authorPereira, Sara B.
dc.contributor.authorBovea-Marco, Miquel
dc.contributor.authorFutschik, Matthias E.
dc.contributor.authorTamagnini, Paula
dc.contributor.authorOliveira, Paulo
dc.date.accessioned2017-04-07T15:56:29Z
dc.date.available2017-04-07T15:56:29Z
dc.date.issued2016-06
dc.description.abstractMetals are essential for all living organisms and required for fundamental biochemical processes. However, when in excess, metals can turn into highly-toxic agents able to disrupt cell membranes, alter enzymatic activities, and damage DNA. Metal concentrations are therefore tightly controlled inside cells, particularly in cyanobacteria. Cyanobacteria are ecologically relevant prokaryotes that perform oxygenic photosynthesis and can be found in many different marine and freshwater ecosystems, including environments contaminated with heavy metals. As their photosynthetic machinery imposes high demands for metals, homeostasis of these micronutrients has been widely studied in cyanobacteria. So far, most studies have focused on how cells are capable of controlling their internal metal pools, with a strong bias toward the analysis of intracellular processes. Ultrastructure, modulation of physiology, dynamic changes in transcription and protein levels have been studied, but what takes place in the extracellular environment when cells are exposed to an unbalanced metal availability remains largely unknown. The interest in studying the subset of proteins present in the extracellular space has only recently begun and the identification and functional analysis of the cyanobacterial exoproteomes are just emerging. Remarkably, metal-related proteins such as the copper-chaperone CopM or the iron-binding protein FutA2 have already been identified outside the cell. With this perspective, we aim to raise the awareness that metal-resistance mechanisms are not yet fully known and hope to motivate future studies assessing the role of extracellular proteins on bacterial metal homeostasis, with a special focus on cyanobacteria.
dc.identifier.doi10.3389/fmicb.2016.00878
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/10400.1/9428
dc.language.isoeng
dc.peerreviewedyes
dc.relationThe regulation of photosynthesis in cyanobacteria: A systems biology approach
dc.relationDeciphering the gene regulatory networks of cyanobacteria
dc.relationCYANOBACTERIAL EXTRACELLULAR POLYMERIC SUBSTANCES EPS FOR HEAVY METAL BIOREMEDIATION: MECHANISMS OF EPS PRODUCTION AND CYANOBACTERIA-METAL INTERACTIONS
dc.relationEXPLORING PROTEIN LOCALIZATION AND SECRETION TO DEVELOP CYANOBACTERIA AS ROBUST BIOTECHNOLOGICAL TOOLS
dc.relation.isbasedonWOS:000377170700001
dc.titleExtracellular proteins: Novel Key components of metal resistance in cyanobacteria?
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe regulation of photosynthesis in cyanobacteria: A systems biology approach
oaire.awardTitleDeciphering the gene regulatory networks of cyanobacteria
oaire.awardTitleCYANOBACTERIAL EXTRACELLULAR POLYMERIC SUBSTANCES EPS FOR HEAVY METAL BIOREMEDIATION: MECHANISMS OF EPS PRODUCTION AND CYANOBACTERIA-METAL INTERACTIONS
oaire.awardTitleEXPLORING PROTEIN LOCALIZATION AND SECRETION TO DEVELOP CYANOBACTERIA AS ROBUST BIOTECHNOLOGICAL TOOLS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIC%2F4418%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00881%2F2013%2FCP1198%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F74894%2F2010/PT
oaire.citation.endPage878
oaire.citation.startPage878
oaire.citation.titleFrontiers in Microbiology
oaire.citation.volume7
oaire.fundingStream3599-PPCDT
oaire.fundingStreamInvestigador FCT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameGiner
person.familyNameFutschik
person.givenNameJoaquin
person.givenNameMatthias
person.identifier336659
person.identifier.ciencia-idA71B-AD01-3501
person.identifier.orcid0000-0003-1553-8295
person.identifier.orcid0000-0002-6245-8071
person.identifier.scopus-author-id55329443800
person.identifier.scopus-author-id14017989400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationfdcd3438-6320-4701-a5ea-ec3df7517a5b
relation.isAuthorOfPublicationd58f3269-c7e1-4c22-b094-5cfe6750821b
relation.isAuthorOfPublication.latestForDiscoveryfdcd3438-6320-4701-a5ea-ec3df7517a5b
relation.isProjectOfPublication50660995-5319-4cb4-bf59-4d5a080d4f55
relation.isProjectOfPublication2994c09a-b440-45c8-abe0-8e0a883d29c6
relation.isProjectOfPublicatione13142f2-37b8-4b5a-b2cd-352e62003184
relation.isProjectOfPublication868b4818-3efa-4edb-9202-c464d64fd38f
relation.isProjectOfPublicationabc78ff3-cb05-4926-8935-edd242cb6a6c
relation.isProjectOfPublicationba3df0b2-0333-49dd-9bcd-085e0c8790e0
relation.isProjectOfPublication.latestForDiscovery50660995-5319-4cb4-bf59-4d5a080d4f55

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
9428.pdf
Size:
1005.43 KB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)