DOP56 Fibrosis-related transcriptome unveils a distinctive matrix remodelling pattern in penetrating but not in stricturing ileal Crohn's Disease

Sousa, Helena Tavares; Ferreira. M.; Gullo, I.; Rocha, A. M.; Oliveira, C.; Carneiro, F.; Magro, F.

http://hdl.handle.net/10400.1/27193

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Authors

Sousa, Helena Tavares

Abstract(s)

Fibrosis underlies most of CD complications requiring surgery, such as intestinal strictures and penetrating events. We previously demonstrated there were no histopathological differences on transmural fibrosis and fibromuscular changesbetween penetrating and stricturing ileal CD. This study aimed to investigate and compare the fibrosis-related transcriptomic profiles of penetrating and stricturing ileal CD.