Publication
Getting a handle on embryo limb development: Molecular interactions driving limb outgrowth and patterning
dc.contributor.author | Sheeba, C.J. | |
dc.contributor.author | Andrade, Raquel P. | |
dc.contributor.author | Palmeirim, Isabel | |
dc.date.accessioned | 2017-04-07T15:57:38Z | |
dc.date.available | 2017-04-07T15:57:38Z | |
dc.date.issued | 2016-07 | |
dc.description.abstract | Development of the vertebrate embryo involves multiple segmentation processes to generate a functional, articulated organism. Cell proliferation, differentiation and patterning involve spatially and temporally regulated gene expression and signal transduction mechanisms. The developing vertebrate limb is an excellent model to study such fine-tuned regulations, whereby cells proliferate and are differentially sculptured along the proximal-distal, anterior-posterior and dorsal-ventral axes to form a functional limb. Complementary experimental approaches in different organisms have enhanced our knowledge on the molecular events underlying limb development. Herein, we summarize the current knowledge of the main signaling mechanisms governing vertebrate limb initiation, outgrowth, specification of limb segments and termination. (C) 2015 Elsevier Ltd. All rights reserved. | |
dc.description.sponsorship | 07-0124-FEDER-000017 | |
dc.identifier.doi | 10.1016/j.semcdb.2015.01.007 | |
dc.identifier.issn | 1084-9521 | |
dc.identifier.other | AUT: IME02311; | |
dc.identifier.uri | http://hdl.handle.net/10400.1/9772 | |
dc.language.iso | eng | |
dc.peerreviewed | yes | |
dc.relation | SHEDDING LIGHT ON THE CONTROVERSY: ESTABLISHING THE EMBRYO MOLECULAR CLOCK AS AN INTEGRAL COMPONENT OF THE LIMB PATTERNING MACHINERY | |
dc.relation | human Mesenchymal Stem Cells Chronobiology: evaluating the crosstalk between the Embryonic and Circadian Clocks | |
dc.relation | Strategic Project - LA 23 - 2011-2012 | |
dc.relation.isbasedon | WOS:000370643900014 | |
dc.title | Getting a handle on embryo limb development: Molecular interactions driving limb outgrowth and patterning | |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.awardTitle | SHEDDING LIGHT ON THE CONTROVERSY: ESTABLISHING THE EMBRYO MOLECULAR CLOCK AS AN INTEGRAL COMPONENT OF THE LIMB PATTERNING MACHINERY | |
oaire.awardTitle | human Mesenchymal Stem Cells Chronobiology: evaluating the crosstalk between the Embryonic and Circadian Clocks | |
oaire.awardTitle | Strategic Project - LA 23 - 2011-2012 | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F89493%2F2012/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MED%2F1063%2F2012/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-BID%2F121459%2F2010/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0023%2F2011/PT | |
oaire.citation.endPage | 101 | |
oaire.citation.startPage | 92 | |
oaire.citation.title | Seminars in Cell and Developmental Biology | |
oaire.citation.volume | 49 | |
oaire.fundingStream | 3599-PPCDT | |
oaire.fundingStream | COMPETE | |
oaire.fundingStream | 6817 - DCRRNI ID | |
person.familyName | Sheeba | |
person.familyName | Andrade | |
person.familyName | Palmeirim | |
person.givenName | Caroline Jeya | |
person.givenName | Raquel | |
person.givenName | Isabel | |
person.identifier | 437977 | |
person.identifier.ciencia-id | 2312-360B-227A | |
person.identifier.ciencia-id | 141A-4DE2-6FF3 | |
person.identifier.orcid | 0000-0001-5357-4743 | |
person.identifier.orcid | 0000-0002-0397-5917 | |
person.identifier.orcid | 0000-0003-2282-7829 | |
person.identifier.rid | B-5177-2011 | |
person.identifier.scopus-author-id | 6504257550 | |
person.identifier.scopus-author-id | 7103114918 | |
person.identifier.scopus-author-id | 6603305227 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
rcaap.rights | openAccess | |
rcaap.type | article | |
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