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Getting a handle on embryo limb development: Molecular interactions driving limb outgrowth and patterning

dc.contributor.authorSheeba, C.J.
dc.contributor.authorAndrade, Raquel P.
dc.contributor.authorPalmeirim, Isabel
dc.date.accessioned2017-04-07T15:57:38Z
dc.date.available2017-04-07T15:57:38Z
dc.date.issued2016-07
dc.description.abstractDevelopment of the vertebrate embryo involves multiple segmentation processes to generate a functional, articulated organism. Cell proliferation, differentiation and patterning involve spatially and temporally regulated gene expression and signal transduction mechanisms. The developing vertebrate limb is an excellent model to study such fine-tuned regulations, whereby cells proliferate and are differentially sculptured along the proximal-distal, anterior-posterior and dorsal-ventral axes to form a functional limb. Complementary experimental approaches in different organisms have enhanced our knowledge on the molecular events underlying limb development. Herein, we summarize the current knowledge of the main signaling mechanisms governing vertebrate limb initiation, outgrowth, specification of limb segments and termination. (C) 2015 Elsevier Ltd. All rights reserved.
dc.description.sponsorship07-0124-FEDER-000017
dc.identifier.doi10.1016/j.semcdb.2015.01.007
dc.identifier.issn1084-9521
dc.identifier.otherAUT: IME02311;
dc.identifier.urihttp://hdl.handle.net/10400.1/9772
dc.language.isoeng
dc.peerreviewedyes
dc.relationSHEDDING LIGHT ON THE CONTROVERSY: ESTABLISHING THE EMBRYO MOLECULAR CLOCK AS AN INTEGRAL COMPONENT OF THE LIMB PATTERNING MACHINERY
dc.relationhuman Mesenchymal Stem Cells Chronobiology: evaluating the crosstalk between the Embryonic and Circadian Clocks
dc.relationStrategic Project - LA 23 - 2011-2012
dc.relation.isbasedonWOS:000370643900014
dc.titleGetting a handle on embryo limb development: Molecular interactions driving limb outgrowth and patterning
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSHEDDING LIGHT ON THE CONTROVERSY: ESTABLISHING THE EMBRYO MOLECULAR CLOCK AS AN INTEGRAL COMPONENT OF THE LIMB PATTERNING MACHINERY
oaire.awardTitlehuman Mesenchymal Stem Cells Chronobiology: evaluating the crosstalk between the Embryonic and Circadian Clocks
oaire.awardTitleStrategic Project - LA 23 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F89493%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MED%2F1063%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-BID%2F121459%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0023%2F2011/PT
oaire.citation.endPage101
oaire.citation.startPage92
oaire.citation.titleSeminars in Cell and Developmental Biology
oaire.citation.volume49
oaire.fundingStream3599-PPCDT
oaire.fundingStreamCOMPETE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSheeba
person.familyNameAndrade
person.familyNamePalmeirim
person.givenNameCaroline Jeya
person.givenNameRaquel
person.givenNameIsabel
person.identifier437977
person.identifier.ciencia-id2312-360B-227A
person.identifier.ciencia-id141A-4DE2-6FF3
person.identifier.orcid0000-0001-5357-4743
person.identifier.orcid0000-0002-0397-5917
person.identifier.orcid0000-0003-2282-7829
person.identifier.ridB-5177-2011
person.identifier.scopus-author-id6504257550
person.identifier.scopus-author-id7103114918
person.identifier.scopus-author-id6603305227
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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