Publication
The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection
| dc.contributor.author | Fernandes, Vitor E. | |
| dc.contributor.author | Ercoli, Giuseppe | |
| dc.contributor.author | Bénard, Alan | |
| dc.contributor.author | Brandl, Carolin | |
| dc.contributor.author | Fahnenstiel, Hannah | |
| dc.contributor.author | Müller-Winkler, Jennifer | |
| dc.contributor.author | Weber, Georg F | |
| dc.contributor.author | Denny, Paul | |
| dc.contributor.author | Nitschke, Lars | |
| dc.contributor.author | Andrew, Peter W | |
| dc.date.accessioned | 2020-05-28T08:46:45Z | |
| dc.date.available | 2020-05-28T08:46:45Z | |
| dc.date.issued | 2020-04 | |
| dc.description.abstract | Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1371/journal.ppat.1008464 | pt_PT |
| dc.identifier.issn | 1553-7366 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/13960 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Public Library of Science | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Negative regulator | pt_PT |
| dc.subject | Protect | pt_PT |
| dc.subject | Roles | pt_PT |
| dc.subject | SIGLEC-G | pt_PT |
| dc.subject | Ligand-binding | pt_PT |
| dc.subject | Responses | pt_PT |
| dc.subject | GM-CSF | pt_PT |
| dc.subject | Susceptibility | pt_PT |
| dc.subject | Innate | pt_PT |
| dc.title | The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 4 | pt_PT |
| oaire.citation.startPage | e1008464 | pt_PT |
| oaire.citation.title | PLoS Pathogens | pt_PT |
| oaire.citation.volume | 16 | pt_PT |
| person.familyName | E. Fernandes | |
| person.givenName | Vitor | |
| person.identifier.ciencia-id | 3811-AC60-F24D | |
| person.identifier.orcid | 0000-0001-5179-2122 | |
| person.identifier.scopus-author-id | 36155199000 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | ebeb7825-b898-4b10-85b9-28915399dde1 | |
| relation.isAuthorOfPublication.latestForDiscovery | ebeb7825-b898-4b10-85b9-28915399dde1 |
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