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The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection

2020Journal article Open access
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dc.contributor.authorFernandes, Vitor E.
dc.contributor.authorErcoli, Giuseppe
dc.contributor.authorBénard, Alan
dc.contributor.authorBrandl, Carolin
dc.contributor.authorFahnenstiel, Hannah
dc.contributor.authorMüller-Winkler, Jennifer
dc.contributor.authorWeber, Georg F.
dc.contributor.authorDenny, Paul
dc.contributor.authorNitschke, Lars
dc.contributor.authorAndrew, Peter W.
dc.date.accessioned2020-09-02T08:41:23Z
dc.date.available2020-09-02T08:41:23Z
dc.date.issued2020
dc.description.abstractStreptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1371/journal.ppat.1008464pt_PT
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/10400.1/14668
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectB-Lymphocytespt_PT
dc.subjectBacteremiapt_PT
dc.subjectFemalept_PT
dc.subjectHost-Pathogen Interactionspt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMicept_PT
dc.subjectMice, Inbred BALB Cpt_PT
dc.subjectMice, Inbred C57BLpt_PT
dc.subjectMice, Inbred CBApt_PT
dc.subjectPneumococcal Infectionspt_PT
dc.subjectPneumonia, Pneumococcalpt_PT
dc.subjectSialic Acid Binding Ig-like Lectin 2pt_PT
dc.subjectStreptococcus pneumoniaept_PT
dc.titleThe B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPagee1008464pt_PT
oaire.citation.titlePLoS Pathogenspt_PT
oaire.citation.volume16pt_PT
person.familyNameDenny
person.givenNamePaul
person.identifier.orcid0000-0003-4659-6893
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb0b3224b-5aeb-4cdb-8ed9-bd83d0017204
relation.isAuthorOfPublication.latestForDiscoveryb0b3224b-5aeb-4cdb-8ed9-bd83d0017204

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