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Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm

2005-11Journal article Open access
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dc.contributor.authorKimura-Yoshida, C.
dc.contributor.authorNakano, H.
dc.contributor.authorOkamura, D.
dc.contributor.authorNakao, K.
dc.contributor.authorYonemura, S.
dc.contributor.authorA. Belo, José
dc.contributor.authorAizawa, S.
dc.contributor.authorMatsui, Y.
dc.contributor.authorMatsuo, I.
dc.date.accessioned2018-12-07T14:58:01Z
dc.date.available2018-12-07T14:58:01Z
dc.date.issued2005-11
dc.description.abstractThe mouse embryonic axis is initially formed with a proximal-distal orientation followed by subsequent conversion to a prospective anterior-posterior (A-P) polarity with directional migration of visceral endoderm cells. Importantly, Otx2, a homeobox gene, is essential to this developmental process. However, the genetic regulatory mechanism governing axis conversion is poorly understood. Here, defective axis conversion due to Otx2 deficiency can be rescued by expression of Dkk1, a Wnt antagonist, or following removal of one copy of the beta-catenin gene. Misexpression of a canonical Wnt ligand can also inhibit correct A-P axis rotation. Moreover, asymmetrical distribution of beta-catenin localization is impaired in the Otx2-deficient and Wnt- misexpressing visceral endoderm. Concurrently, canonical Wnt and Dkk1 function as repulsive and attractive guidance cues, respectively, in the migration of visceral endoderm cells. We propose that Wnt/beta-catenin signaling mediates A-P axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.devcel.2005.09.011
dc.identifier.issn1534-5807
dc.identifier.urihttp://hdl.handle.net/10400.1/11818
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCell Press
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNuclear beta-catenin
dc.subjectHead induction
dc.subjectEmbryo
dc.subjectGene
dc.subjectEpiblast
dc.subjectOtx2
dc.subjectSpecification
dc.subjectAsymmetry
dc.subjectMovement
dc.subjectProteins
dc.titleCanonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage650
oaire.citation.issue5
oaire.citation.startPage639
oaire.citation.titleDevelopmental Cell
oaire.citation.volume9
person.familyNameBelo
person.givenNameJosé A.
person.identifier.ciencia-idBF13-08E9-25E6
person.identifier.orcid0000-0001-7384-0949
person.identifier.ridF-4444-2012
person.identifier.scopus-author-id6602141392
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication4bebeb48-6fac-41a9-8363-f849def5e019
relation.isAuthorOfPublication.latestForDiscovery4bebeb48-6fac-41a9-8363-f849def5e019

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