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The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa

2007-06Journal article Open Access
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dc.contributor.authorSisowath, Christin
dc.contributor.authorFerreira, Pedro E.
dc.contributor.authorBustamante, Leyla Y.
dc.contributor.authorDahlstrom, Sabina
dc.contributor.authorMartensson, Andreas
dc.contributor.authorBjorkman, Anders
dc.contributor.authorKrishna, Sanjeev
dc.contributor.authorGil, José Pedro
dc.date.accessioned2018-12-07T14:53:35Z
dc.date.available2018-12-07T14:53:35Z
dc.date.issued2007-06
dc.description.abstractObjective Artemether-lumefantrine (AL), presently the most favoured combination therapy against uncomplicated Plasmodium falciparum malaria in Africa, has recently shown to select for the pfmdr1 86N allele. The objective of this study was to search for the selection of other mutations potentially involved in artemether-lumefantrine tolerance and/or resistance, i.e. pfmdr1 gene amplification, pfmdr1 Y184F, S1034C, N1042D, D1246Y, pfcrt S163R and PfATP6 S769N. Methods The above mentioned SNPs were analysed by PCR-restriction fragment length polymorphism and pfmdr1 gene amplification by real-time PCR based protocols in parasites from 200 children treated with AL for uncomplicated P. falciparum malaria in Zanzibar. Results A statistically significant selection of pfmdr1 184F mostly in combination with 86N was seen in reinfections after treatment. No pfmdr1 gene amplification was found. Conclusion The results suggest that different pfmdr1 alleles are involved in the development of tolerance/resistance to lumefantrine.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1111/j.1365-3156.2007.01843.x
dc.identifier.issn1360-2276
dc.identifier.issn1365-3156
dc.identifier.urihttp://hdl.handle.net/10400.1/11582
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley-Blackwell
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSub-Saharan Africa
dc.subjectMefloquine resistance
dc.subjectIncreased sensitivity
dc.subjectGene
dc.subjectSelection
dc.subjectMalaria
dc.subjectAmplification
dc.subjectHalofantrine
dc.subjectAmodiaquine
dc.subjectMutations
dc.titleThe role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage742
oaire.citation.issue6
oaire.citation.startPage736
oaire.citation.titleTropical Medicine and International Health
oaire.citation.volume12
person.familyNameFerreira
person.familyNameGil
person.givenNamePedro
person.givenNameJosé Pedro
person.identifier332675
person.identifier.ciencia-id5E15-DD6D-50E6
person.identifier.ciencia-idD01A-B30E-BCD5
person.identifier.orcid0000-0002-2682-7722
person.identifier.orcid0000-0002-6107-9379
person.identifier.ridQ-6748-2016
person.identifier.scopus-author-id55427200100
person.identifier.scopus-author-id7201625436
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicatione0a51049-1676-475b-a9e8-1d911386238d
relation.isAuthorOfPublicationcb728715-0e4c-4ae5-9e21-b6a8f35a8313
relation.isAuthorOfPublication.latestForDiscoverycb728715-0e4c-4ae5-9e21-b6a8f35a8313

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