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Determining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohort

2020Journal article Open Access
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dc.contributor.authorPD, Carvalho
dc.contributor.authorRuyssen-Witrand, Adeline
dc.contributor.authorFonseca, Joao
dc.contributor.authorMarreiros, Ana
dc.contributor.authorMachado, Pedro M
dc.date.accessioned2021-02-12T14:28:58Z
dc.date.available2021-02-12T14:28:58Z
dc.date.issued2020
dc.description.abstractObjective To investigate the determinants of impaired spinal and hip mobility in patients with early axial spondyloarthritis (axSpA). Methods Five-year longitudinal data from the DEvenir des Spondyloarthrites Indifferenciees Recentes (DESIR) cohort were analysed. Associations were investigated using generalised estimating equations, using Bath Ankylosing Spondylitis Metrology Index (BASMI) linear or each of the five components of BASMI as dependent variables, and clinical and demographic variables as independent variables in univariable models. Multivariable analyses were performed, adjusting for potential confounders. Results Data from 644 patients and 5152 visits were analysed. Higher BASMI values were independently and positively associated with Ankylosing Spondylitis Disease Activity Score C reactive protein (ASDAS-CRP) (adjusted B (adjB)=0.21; 95% CI=0.15 to 0.28), MRI spinal inflammation score (adjB=0.11; 95% CI=0.04 to 0.19), enthesitis score (adjB=0.02; 95% CI=0.01 to 0.04) and age (adjB=0.02; 95% CI=0.01 to 0.03). All BASMI components were independently associated with ASDAS-CRP and MRI spinal inflammation, except for maximal intermalleolar distance (reflecting hip mobility), which was not associated with MRI spinal inflammation. Conclusion In early axSpA, spinal mobility impairment is independently determined by clinical disease activity, MRI spinal inflammation, enthesitis and age. The influence of spinal inflammation prevails in early axSpA, as opposed to spinal structural damage, which may become more relevant in later disease stages.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1136/rmdopen-2020-001356pt_PT
dc.identifier.issn2056-5933
dc.identifier.urihttp://hdl.handle.net/10400.1/15082
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectSpondylitispt_PT
dc.subjectPatient reported outcome measurespt_PT
dc.subjectAnkylosingpt_PT
dc.subjectMRIpt_PT
dc.titleDetermining factors related to impaired spinal and hip mobility in patients with axial spondyloarthritis: longitudinal results from the DESIR cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPagee001356pt_PT
oaire.citation.titleRMD Openpt_PT
oaire.citation.volume6pt_PT
person.familyNameCarvalho
person.familyNameMarreiros
person.givenNamePedro David
person.givenNameAna
person.identifier.ciencia-id9A12-9450-7051
person.identifier.orcid0000-0001-8255-4274
person.identifier.orcid0000-0001-9410-4772
person.identifier.ridI-4379-2016
person.identifier.scopus-author-id57194785077
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8695cb83-0deb-4735-82b2-6f0cc3f2d085
relation.isAuthorOfPublicationc0a8e5da-26ae-42a8-ab04-fa4df4356375
relation.isAuthorOfPublication.latestForDiscoveryc0a8e5da-26ae-42a8-ab04-fa4df4356375

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