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Combination of naltrexone and isotretinoin for the treatment of darier disease

2023-01-03Artigo científico Acesso aberto
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dc.contributor.authorCosta, Tomás
dc.contributor.authorRebelo, Clarisse
dc.contributor.authorPinto, Gabriela Marques
dc.contributor.authorDuarte, Bruno
dc.date.accessioned2025-03-13T09:35:29Z
dc.date.available2025-03-13T09:35:29Z
dc.date.issued2023-01-03
dc.description.abstractDarier disease (DD) is an autosomal-dominant genodermatosis in which mutations in the ATP2A2 gene result in impaired intercellular adhesion and epidermal blistering. Treatment options usually rely on systemic retinoids, but a refractory disease is still a therapeutical challenge. Given the similarity of DD pathogenesis with Hailey-Hailey disease, concomitant treatment with low-dose-naltrexone (LDN) has been proposed. We present the case of a 34-year-old woman with a 20-year history of severe, biopsy-proven DD, previously treated with several unsuccessful topical and systemic treatments, including oral isotretinoin, cyclosporine, doxycycline, methotrexate, acitretin, and subcutaneous adalimumab. At presentation, she had widespread keratotic, crusted, brown papules on her trunk and proximal extremities. Treatment with oral LDN (4.5 mg/day in manipulated tablets) was then initiated while maintaining the current isotretinoin therapy. After three months, there was a nearly complete clearance of the lesions, and no adverse effects were reported.eng
dc.identifier.doi10.7759/cureus.33321
dc.identifier.issn2168-8184
dc.identifier.urihttp://hdl.handle.net/10400.1/26898
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Science and Business Media LLC
dc.relation.hasversionhttps://www.cureus.com/articles/130848-combination-of-naltrexone-and-isotretinoin-for-the-treatment-of-darier-disease#!/
dc.relation.ispartofCureus
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectClinical dermatology
dc.subjectDarier disease
dc.subjectDermatology case report
dc.subjectGenodermatoses
dc.subjectLow-dose naltrexone
dc.titleCombination of naltrexone and isotretinoin for the treatment of darier diseaseeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPagee33321
oaire.citation.titleCureus: Journal of Medical Science
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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