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Accuracy of faecal calprotectin and neutrophil Gelatinase B-associated Lipocalin in evaluating subclinical inflammation in UlceRaTIVE colitis-the ACERTIVE study

2017-04Journal article Open access
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dc.contributor.authorMagro, Fernando
dc.contributor.authorLopes, Susana
dc.contributor.authorCoelho, Rosa
dc.contributor.authorCotter, Jose
dc.contributor.authorCastro, Francisca Dias de
dc.contributor.authorSousa, Helena Tavares
dc.contributor.authorSalgado, Marta
dc.contributor.authorAndrade, PatrĂ­cia
dc.contributor.authorVieira, Ana Isabel
dc.contributor.authorFigueiredo, Pedro
dc.contributor.authorCaldeira, Paulo
dc.contributor.authorSousa, A.
dc.contributor.authorDuarte, Maria A.
dc.contributor.authorAvila, Filipa
dc.contributor.authorSilva, JoĂŁo
dc.contributor.authorMoleiro, Joana
dc.contributor.authorMendes, Sofia
dc.contributor.authorGiestas, Silvia
dc.contributor.authorMinistro, Paula
dc.contributor.authorSousa, Paula
dc.contributor.authorGonçalves, Raquel
dc.contributor.authorGonçalves, Bruno
dc.contributor.authorOliveira, Ana
dc.contributor.authorChagas, Cristina
dc.contributor.authorTorres, Joana
dc.contributor.authorDias, Claudia Camila
dc.contributor.authorLopes, Joanne
dc.contributor.authorBorralho, Paula
dc.contributor.authorAfonso, Joana
dc.contributor.authorGeboes, Karel
dc.contributor.authorCarneiro, FĂĄtima
dc.date.accessioned2018-12-07T14:52:27Z
dc.date.available2018-12-07T14:52:27Z
dc.date.issued2017-04
dc.description.abstractBackground and Aims: Mucosal healing and histological remission are different targets for patients with ulcerative colitis, but both rely on an invasive endoscopic procedure. This study aimed to assess faecal calprotectin and neutrophil gelatinase B-associated lipocalin as biomarkers for disease activity in asymptomatic ulcerative colitis patients. Methods: This was a multicentric cross-sectional study including 371 patients, who were classified according to their endoscopic and histological scores. These results were evaluated alongside the faecal levels of both biomarkers. Results: Macroscopic lesions [i.e. endoscopic Mayo score >= 1] were present in 28% of the patients, and 9% had active disease according to fht Ulcerative Colitis Endoscopic Index of Severity. Moreover, 21% presented with histological inflammation according to the Geboes index, whereas 15% and 5% presented with focal and diffuse basal plasmacytosis, respectively. The faecal levels of calprotectin and neutrophil gelatinase B-associated lipocalin were statistically higher for patients with endoscopic lesions and histological activity. A receiver operating characteristic-based analysis revealed that both biomarkers were able to indicate mucosal healing and histological remission with an acceptable probability, and cut-off levels of 150-250 mu g/g for faecal calprotectin and 12 mu g/g for neutrophil gelatinase B-associated lipocalin were proposed. Conclusions: Faecal calprotectin and neutrophil gelatinase B-associated lipocalin levels are a valuable addition for assessment of disease activity in asymptomatic ulcerative colitis patients. Biological levels of the analysed biomarkers below the proposed thresholds can rule out the presence of macroscopic and microscopic lesions with a probability of 75-93%. However, caution should be applied whenever interpreting positive results, as these biomarkers present consistently low positive predictive values.
dc.description.sponsorshipPortuguese IBD Group [GEDII - Grupo de Estudo da Doenca Inflamatcria Intestinal]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1093/ecco-jcc/jjw170
dc.identifier.issn1873-9946
dc.identifier.issn1876-4479
dc.identifier.urihttp://hdl.handle.net/10400.1/11084
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBowel-disease
dc.subjectMatrix-Metalloproteinase-9 Complex
dc.subjectHistologic inflammation
dc.subjectColorectal neoplasia
dc.subjectCrohns-disease
dc.subjectRisk-factor
dc.subjectRelapse
dc.subjectMarker
dc.subjectRemission
dc.subjectSeverity
dc.titleAccuracy of faecal calprotectin and neutrophil Gelatinase B-associated Lipocalin in evaluating subclinical inflammation in UlceRaTIVE colitis-the ACERTIVE study
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage444
oaire.citation.issue4
oaire.citation.startPage435
oaire.citation.titleJournal of Crohn's and Colitis
oaire.citation.volume11
person.familyNameSousa
person.familyNameCaldeira
person.givenNameHelena Tavares
person.givenNamePaulo
person.identifier.ciencia-idCF1F-1163-1C4A
person.identifier.ciencia-id1112-F0B2-19A3
person.identifier.orcid0000-0002-6626-205X
person.identifier.orcid0000-0002-2404-6295
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication6b1d11dd-486f-4fb3-b41f-02e1cf6a5c2e
relation.isAuthorOfPublication3def3720-8982-4c46-801d-af640d508b59
relation.isAuthorOfPublication.latestForDiscovery3def3720-8982-4c46-801d-af640d508b59

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