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UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks

2014-01Journal article Open access
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dc.contributor.authorKalathur, Ravi Kiran Reddy
dc.contributor.authorPinto, Jose Pedro
dc.contributor.authorHernandez-Prieto, Miguel A.
dc.contributor.authorMachado, Rui
dc.contributor.authorAlmeida, Dulce
dc.contributor.authorChaurasia, Gautam
dc.contributor.authorFutschik, Matthias E.
dc.date.accessioned2018-12-07T14:53:08Z
dc.date.available2018-12-07T14:53:08Z
dc.date.issued2014-01
dc.description.abstractUnified Human Interactome (UniHI) (http://www.unihi.org) is a database for retrieval, analysis and visualization of human molecular interaction networks. Its primary aim is to provide a comprehensive and easy-to-use platform for network-based investigations to a wide community of researchers in biology and medicine. Here, we describe a major update (version 7) of the database previously featured in NAR Database Issue. UniHI 7 currently includes almost 350 000 molecular interactions between genes, proteins and drugs, as well as numerous other types of data such as gene expression and functional annotation. Multiple options for interactive filtering and highlighting of proteins can be employed to obtain more reliable and specific network structures. Expression and other genomic data can be uploaded by the user to examine local network structures. Additional built-in tools enable ready identification of known drug targets, as well as of biological processes, phenotypes and pathways enriched with network proteins. A distinctive feature of UniHI 7 is its user-friendly interface designed to be utilized in an intuitive manner, enabling researchers less acquainted with network analysis to perform state-of-the-art network-based investigations.
dc.description.sponsorshipPortuguese Fundacao para a Ciencia e a Tecnologia (FCT) [PTDC/BIA-GEN/116519/2010]; CHDI Foundation [A-2666]; FCT [SFRH/BPD/70718/2010, PTDC/BIA-BCM/117975/2010]; Portuguese Fundacao para a Ciencia e a Tecnologia [PTDC/BIA-GEN/116519/2010]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1093/nar/gkt1100
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.urihttp://hdl.handle.net/10400.1/11370
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.relationSYSTEMS BIOLOGY APPROACH TO UNRAVEL THE MOLECULAR MECHANISMS INVOLVED IN T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA
dc.relationThe role and regulation of alpha-synuclein phosphorylation in both pathological and physiological conditions
dc.relationAlternative splicing and its impact on molecular networks during stem cell differentiation
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectProtein interaction network
dc.subject2013 Update
dc.subjectBiology
dc.subjectIntegration
dc.subjectWeb
dc.subjectVisualization
dc.subjectResources
dc.subjectDisease
dc.subjectServer
dc.subjectGenes
dc.titleUniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSYSTEMS BIOLOGY APPROACH TO UNRAVEL THE MOLECULAR MECHANISMS INVOLVED IN T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA
oaire.awardTitleThe role and regulation of alpha-synuclein phosphorylation in both pathological and physiological conditions
oaire.awardTitleAlternative splicing and its impact on molecular networks during stem cell differentiation
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F70718%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BCM%2F117975%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-GEN%2F116519%2F2010/PT
oaire.citation.endPageD414
oaire.citation.issueD1
oaire.citation.startPageD408
oaire.citation.titleNucleic Acids Research
oaire.citation.volume42
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameKalathur
person.familyNameHernández-Prieto
person.familyNameMachado
person.familyNameAlmeida
person.familyNameFutschik
person.givenNameRavi Kiran Reddy
person.givenNameMiguel Angel
person.givenNameRui
person.givenNameDulce
person.givenNameMatthias
person.identifier.ciencia-id5D19-8F5F-3CE1
person.identifier.ciencia-idA71B-AD01-3501
person.identifier.orcid0000-0003-2894-3345
person.identifier.orcid0000-0001-7950-1526
person.identifier.orcid0000-0002-4080-2353
person.identifier.orcid0000-0002-1399-4062
person.identifier.orcid0000-0002-6245-8071
person.identifier.scopus-author-id22940879800
person.identifier.scopus-author-id26430696600
person.identifier.scopus-author-id55991033900
person.identifier.scopus-author-id14017989400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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