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Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo

2008-03Journal article Open access
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dc.contributor.authorLiguori, Giovanna
dc.contributor.authorBorges, Ana
dc.contributor.authorD'Andrea, Daniela
dc.contributor.authorLiguoro, Annamaria
dc.contributor.authorGonçalves Dias da Silva, Lisa
dc.contributor.authorSalizueiro, Ana Marisa
dc.contributor.authorPersico, M. Graziella
dc.contributor.authorBelo, José A.
dc.date.accessioned2018-12-07T14:53:45Z
dc.date.available2018-12-07T14:53:45Z
dc.date.issued2008-03
dc.description.abstractDuring early mouse development, the TGF beta-related protein Nodal specifies the organizing centers that control the formation of the anterior-posterior (A-P) axis. EGF-CFC proteins are important components of the Nodal signaling pathway, most likely by acting as Nodal coreceptors. However, the extent to which Nodal activity depends on EGF-CFC proteins is still debated. Cripto is the earliest EGF-CFC gene expressed during mouse embryogenesis and is involved in both A-P axis orientation and mesoderm formation. To investigate the relation between Cripto and Nodal in the early mouse embryo, we removed the Nodal antagonist Cerberus 1 (Cer1) and simultaneously Cripto, by generating Cer1;Cripto double mouse mutants. We observed that two thirds of the Cer1,Cripto double mutants are rescued in processes that are severely compromised in Cripto(-/-) embryos, namely A-P axis orientation, anterior mesendoderm and posterior neuroectoderin formation. The observed rescue is strongly reduced in Cer1;Cripto;Nodal triple mutants, suggesting that Nodal can signal extensively in the absence of Cripto, if Cer1 is also inhibited. This signaling activity drives A-P axis positioning. Our results provide evidence for the existence. of Cripto-independent signaling mechanisms, by which Nodal controls axis specification in the early mouse embryo. (C) 2007 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.ydbio.2007.12.027
dc.identifier.issn0012-1606
dc.identifier.urihttp://hdl.handle.net/10400.1/11668
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAcademic Press Inc Elsevier Science
dc.subjectAnterior Visceral Endoderm
dc.subjectIi Activin Receptors
dc.subjectTgf-Beta Signals
dc.subjectVertebrate Development
dc.subjectNeuralizing Activity
dc.subjectPrimitive Endoderm
dc.subjectPosterior Axis
dc.subjectCerberus-Like
dc.subjectGastrulation
dc.subjectEpiblast
dc.titleCripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage289
oaire.citation.issue2
oaire.citation.startPage280
oaire.citation.titleDevelopmental Biology
oaire.citation.volume315
person.familyNameBorges
person.familyNameGonçalves Dias da Silva
person.familyNameBelo
person.givenNameAna
person.givenNameLisa
person.givenNameJosé A.
person.identifier.ciencia-idBF13-08E9-25E6
person.identifier.orcid0000-0002-2572-6823
person.identifier.orcid0000-0002-3431-5217
person.identifier.orcid0000-0001-7384-0949
person.identifier.ridF-4444-2012
person.identifier.scopus-author-id57190066063
person.identifier.scopus-author-id14421240100
person.identifier.scopus-author-id6602141392
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication48352462-c3d8-4d19-bf45-efc075a6074d
relation.isAuthorOfPublication6cc4141c-3a50-4075-9b9b-903bb54ffb67
relation.isAuthorOfPublication4bebeb48-6fac-41a9-8363-f849def5e019
relation.isAuthorOfPublication.latestForDiscovery4bebeb48-6fac-41a9-8363-f849def5e019

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