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Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands

2012-07Journal article Open access
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dc.contributor.authorCavaco, I.
dc.contributor.authorPiedade, R.
dc.contributor.authorMsellem, M. I.
dc.contributor.authorBjorkman, A.
dc.contributor.authorGil, José Pedro
dc.date.accessioned2018-12-07T14:53:21Z
dc.date.available2018-12-07T14:53:21Z
dc.date.issued2012-07
dc.description.abstractAmodiaquine (AQ) is a 4-aminoquinoline widely used in the treatment of malaria as part of the artemisinin combination therapy (ACT). AQ is metabolised towards its main metabolite desethylamodiaquine mainly by cytochrome P450 2C8 (CYP2C8). CYP1A1 and CYP1B1 play a minor role in the metabolism but they seem to be significantly involved in the formation of the short-lived quinine-imine. To complete the genetic variation picture of the main genes involved in AQ metabolism in the Zanzibar population, previously characterised for CYP2C8, we analysed in this study CYP1A1 and CYP1B1 main genetic polymorphisms. The results obtained show a low frequency of the CYP1A1*2B/C allele (2.4%) and a high frequency of CYP1B1*6 (approximately 42%) followed by CYP1B1*2 (approximately 27%) in Zanzibar islands. Genotype data for CYP1A1 and CYP1B1 show a low incidence of fast metabolisers, revealing a relatively safe genetic background in Zanzibars population regarding the appearance of adverse effects.
dc.description.sponsorshipPortuguese Foundation for Science and Technology [SFRH/BPD/34152/2006, IBB/CBME, LA, FEDER/POCI 2010]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1111/j.1365-3156.2012.03011.x
dc.identifier.issn1360-2276
dc.identifier.urihttp://hdl.handle.net/10400.1/11469
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley-Blackwell
dc.relationMOLECULAR GENETIC AND ENZYMATIC BASIS OF INTERINDIVIDUAL AND INTERETHNIC DIFFERENCES IN DRUG METABOLISM
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFunctional-analysis
dc.subjectMalaria patients
dc.subjectBreast-cancer
dc.subjectAmodiaquine
dc.subjectPolymorphism
dc.subjectMetabolism
dc.subjectBioactivation
dc.subjectLeukocytes
dc.subjectVariants
dc.subjectReceptor
dc.titleCytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMOLECULAR GENETIC AND ENZYMATIC BASIS OF INTERINDIVIDUAL AND INTERETHNIC DIFFERENCES IN DRUG METABOLISM
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F34152%2F2006/PT
oaire.citation.endPage857
oaire.citation.issue7
oaire.citation.startPage854
oaire.citation.titleTropical Medicine and International Health
oaire.citation.volume17
person.familyNameGil
person.givenNameJosé Pedro
person.identifier.ciencia-idD01A-B30E-BCD5
person.identifier.orcid0000-0002-6107-9379
person.identifier.scopus-author-id7201625436
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscoverycb728715-0e4c-4ae5-9e21-b6a8f35a8313
relation.isProjectOfPublicationb82a552a-eeb8-4416-a2b1-05d8977f878a
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