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Neuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease

2020Journal article Open access
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dc.contributor.authorSilva, Dina
dc.contributor.authorCardoso, Sandra
dc.contributor.authorGuerreiro, Manuela
dc.contributor.authorMaroco, Joao
dc.contributor.authorMendes, Tiago
dc.contributor.authorAlves, Luisa
dc.contributor.authorNogueira, Joana
dc.contributor.authorBaldeiras, Ines
dc.contributor.authorSantana, Isabel
dc.contributor.authorde Mendonca, Alexandre
dc.date.accessioned2021-06-24T11:36:07Z
dc.date.available2021-06-24T11:36:07Z
dc.date.issued2020
dc.description.abstractBackground: Diagnosis of Alzheimer's disease (AD) confirmed by biomarkers allows the patient to make important life decisions. However, doubt about the fleetness of symptoms progression and future cognitive decline remains. Neuropsychological measures were extensively studied in prediction of time to conversion to dementia for mild cognitive impairment (MCI) patients in the absence of biomarker information. Similar neuropsychological measures might also be useful to predict the progression to dementia in patients with MCI due to AD. Objective: To study the contribution of neuropsychological measures to predict time to conversion to dementia in patients with MCI due to AD. Methods: Patients with MCI due toADwere enrolled from a clinical cohort and the effect of neuropsychological performance on time to conversion to dementia was analyzed. Results: At baseline, converters scored lower than non-converters at measures of verbal initiative, non-verbal reasoning, and episodic memory. The test of non-verbal reasoning was the only statistically significant predictor in a multivariate Cox regression model. A decrease of one standard deviation was associated with 29% of increase in the risk of conversion to dementia. Approximately 50% of patients with more than one standard deviation below the mean in the z score of that test had converted to dementia after 3 years of follow-up. Conclusion: In MCI due to AD, lower performance in a test of non-verbal reasoning was associated with time to conversion to dementia. This test, that reveals little decline in the earlier phases of AD, appears to convey important information concerning conversion to dementia.
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia (FCT)Portuguese Foundation for Science and TechnologyEuropean Commission [PTDC/MED-NEU/27946/2017]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3233/JAD-191133
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/10400.1/16636
dc.language.isoeng
dc.peerreviewedyes
dc.publisherIOS Press
dc.subjectAlzheimer's disease (AD)
dc.subjectAmyloid-beta
dc.subjectCognitive impairment
dc.subjectDementia
dc.subjectMild cognitive impairment due to AD
dc.subjectEuropsychological assessment
dc.subjectProdromal AD
dc.subjectRaven coloured progressive matrices
dc.titleNeuropsychological contribution to predict conversion to dementia in patients with mild cognitive impairment due to Alzheimer's disease
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FSOC%2F04020%2F2013/PT
oaire.citation.endPage796
oaire.citation.issue3
oaire.citation.startPage785
oaire.citation.titleJournal of Alzheimers Disease
oaire.citation.volume74
oaire.fundingStream5876
person.familyNameSilva
person.givenNameDina
person.identifier.orcid0000-0003-4437-2765
person.identifier.scopus-author-id26657734400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscoveryadb36ab3-1d97-48a3-b8df-544bef7c7aa0
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relation.isProjectOfPublication.latestForDiscoveryd929dde6-e7fa-4824-aba6-9f5e14a1e1be

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