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The contribution of genetics and environment to obesity

2017-09Journal article Restricted access
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dc.contributor.authorAlbuquerque, David
dc.contributor.authorNóbrega, Clévio
dc.contributor.authorManco, Licínio
dc.contributor.authorPadez, Cristina
dc.date.accessioned2019-11-20T15:07:22Z
dc.date.available2019-11-20T15:07:22Z
dc.date.issued2017-09
dc.description.abstractBackground: Obesity is a global health problem mainly attributed to lifestyle changes such as diet, low physical activity or socioeconomics factors. However, several evidences consistently showed that genetics contributes significantly to the weight-gain susceptibility. Sources of data: A systematic literature search of most relevant original, review and meta-analysis, restricted to English was conducted in PubMed, Web of Science and Google scholar up to May 2017 concerning the contribution of genetics and environmental factors to obesity. Areas of agreement: Several evidences suggest that obesogenic environments contribute to the development of an obese phenotype. However, not every individual from the same population, despite sharing the same obesogenic environment, develop obesity. Areas of controversy: After more than 10 years of investigation on the genetics of obesity, the variants found associated with obesity represent only 3% of the estimated BMI-heritability, which is around 47-80%. Moreover, genetic factors per se were unable to explain the rapid spread of obesity prevalence. Growing points: The integration of multi-omics data enables scientists having a better picture and to elucidate unknown pathways contributing to obesity. Areas timely for developing research: New studies based on case-control or gene candidate approach will be important to identify new variants associated with obesity susceptibility and consequently unveiling its genetic architecture. This will lead to an improvement of our understanding about underlying mechanisms involved in development and origin of the actual obesity epidemic. The integration of several omics will also provide insights about the interplay between genes and environments contributing to the obese phenotype.
dc.description.sponsorshipFundacao para a Ciencia e a Tecnologia (FCT) [UID/ANT/00283/2013]
dc.description.sponsorshipFCT [SFRH/BPD/109043/2015]
dc.description.sponsorshipFCT, Portugal
dc.description.sponsorshipFrench Muscular Dystrophy Association, France
dc.description.sponsorshipFundacao para a Ciencia e a Tecnologia (FCT) [UID/ANT/00283/2013]
dc.description.sponsorshipFCT [SFRH/BPD/109043/2015]
dc.description.sponsorshipFCT, Portugal
dc.description.sponsorshipFrench Muscular Dystrophy Association, France
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1093/bmb/ldx022
dc.identifier.issn0007-1420
dc.identifier.issn1471-8391
dc.identifier.urihttp://hdl.handle.net/10400.1/13002
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBody-mass index
dc.subjectGenome-wide association
dc.subjectFto Rs9939609 polymorphism
dc.subjectPhysical-activity
dc.subjectSocioeconomic-status
dc.subjectFat mass
dc.subjectChildhood overweight
dc.subjectFamily income
dc.subjectVariants
dc.subjectRisk
dc.titleThe contribution of genetics and environment to obesity
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FANT%2F00283%2F2013/PT
oaire.citation.endPage173
oaire.citation.issue1
oaire.citation.startPage159
oaire.citation.titleBritish Medical Bulletin
oaire.citation.volume123
oaire.fundingStream5876
person.familyNameNóbrega
person.familyNamePadez
person.givenNameClévio
person.givenNameCristina
person.identifier.ciencia-idC510-7F41-BAF8
person.identifier.ciencia-idD818-BA39-B3E2
person.identifier.orcid0000-0002-8312-5292
person.identifier.orcid0000-0002-1967-3497
person.identifier.ridM-6047-2013
person.identifier.scopus-author-id24473454000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication31602a52-ba00-49ec-8239-032d82aab846
relation.isAuthorOfPublication.latestForDiscovery725ea6f8-1363-4cee-9cf2-5ac7303b3ba9
relation.isProjectOfPublication248f3429-b606-464b-96b8-995d2765af8f
relation.isProjectOfPublication.latestForDiscovery248f3429-b606-464b-96b8-995d2765af8f

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