Repository logo
 
Publication

Patterning in time and space: HoxB cluster gene expression in the developing chick embryo

2015-01Journal article Open access
Simple item page
dc.contributor.authorGouveia, Analuce
dc.contributor.authorMarcelino, Hugo M.
dc.contributor.authorGonçalves, Lisa
dc.contributor.authorPalmeirim, Isabel
dc.contributor.authorAndrade, Raquel P.
dc.date.accessioned2018-12-07T14:53:07Z
dc.date.available2018-12-07T14:53:07Z
dc.date.issued2015-01
dc.description.abstractThe developing embryo is a paradigmatic model to study molecular mechanisms of time control in Biology. Hox genes are key players in the specification of tissue identity during embryo development and their expression is under strict temporal regulation. However, the molecular mechanisms underlying timely Hox activation in the early embryo remain unknown. This is hindered by the lack of a rigorous temporal framework of sequential Hox expression within a single cluster. Herein, a thorough characterization of HoxB cluster gene expression was performed over time and space in the early chick embryo. Clear temporal collinearity of HoxB cluster gene expression activation was observed. Spatial collinearity of HoxB expression was evidenced in different stages of development and in multiple tissues. Using embryo explant cultures we showed that HoxB2 is cyclically expressed in the rostral presomitic mesoderm with the same periodicity as somite formation, suggesting a link between timely tissue specification and somite formation. We foresee that the molecular framework herein provided will facilitate experimental approaches aimed at identifying the regulatory mechanisms underlying Hox expression in Time and Space.
dc.description.sponsorshipFundacao para a Ciencia e a Tecnologia (FCT), Portugal [PTDC/SAU-OBD/105111/2008, UMINHO/BI/7/2014, SFRH/BPD/65652/2009]; Ciencia Program Contract; Programa Operacional Regional do Norte (ON. 2) [NORTE-07-0124-FEDER-000017]; FCT (National and FEDER COMPETE Program) [PTDC/SAU-BID/121459/2010, PTDC/SAU-OBD/099758/2008]; [PEst-OE/EQB/LA0023/2011]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.4161/15384101.2014.972868
dc.identifier.issn1538-4101
dc.identifier.issn1551-4005
dc.identifier.urihttp://hdl.handle.net/10400.1/11360
dc.language.isoeng
dc.peerreviewedyes
dc.publisherLandes Bioscience
dc.relationThe role of molecular clock genes in temporal control of mesoderm patterning in vertebrate embryos
dc.relationSTUDY OF PUTATIVE INTERACTIONS BETWEEN THE EMBRYO SEGMENTATION CLOCK AND MOLECULAR PLAYERS OF THE CIRCADIAN CLOCK
dc.relationMolecular parallelisms in vertebrate somitogenesis and limb development
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSegmentation clock
dc.subjectVertebrate embryo
dc.subjectGastrulation
dc.subjectMesoderm
dc.subjectEstablishment
dc.subjectInformation
dc.subjectMorphology
dc.subjectAsymmetry
dc.subjectMouse
dc.titlePatterning in time and space: HoxB cluster gene expression in the developing chick embryo
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleThe role of molecular clock genes in temporal control of mesoderm patterning in vertebrate embryos
oaire.awardTitleSTUDY OF PUTATIVE INTERACTIONS BETWEEN THE EMBRYO SEGMENTATION CLOCK AND MOLECULAR PLAYERS OF THE CIRCADIAN CLOCK
oaire.awardTitleMolecular parallelisms in vertebrate somitogenesis and limb development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-OBD%2F105111%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F65652%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-BID%2F121459%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-OBD%2F099758%2F2008/PT
oaire.citation.endPage145
oaire.citation.issue1
oaire.citation.startPage135
oaire.citation.titleCell Cycle
oaire.citation.volume14
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamCOMPETE
oaire.fundingStream3599-PPCDT
person.familyNamePalmeirim
person.familyNameAndrade
person.givenNameIsabel
person.givenNameRaquel
person.identifier.ciencia-id141A-4DE2-6FF3
person.identifier.ciencia-id2312-360B-227A
person.identifier.orcid0000-0003-2282-7829
person.identifier.orcid0000-0002-0397-5917
person.identifier.scopus-author-id6603305227
person.identifier.scopus-author-id7103114918
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication19d625d8-5aae-462b-b83a-ad10a155897f
relation.isAuthorOfPublicationf2d3fc39-a8f6-4d83-9e60-2e2fdfbc2b4a
relation.isAuthorOfPublication.latestForDiscovery19d625d8-5aae-462b-b83a-ad10a155897f
relation.isProjectOfPublication1a6a7977-a57a-4b19-a2a8-ee5eb5d1cabe
relation.isProjectOfPublication85d6361b-3f06-47b4-9c91-55ec48423222
relation.isProjectOfPublication37beaf0f-8836-4e26-a95e-54ed7b17d6ed
relation.isProjectOfPublication5d05af5f-2d78-4436-8d7e-4360d6b3c246
relation.isProjectOfPublication.latestForDiscovery5d05af5f-2d78-4436-8d7e-4360d6b3c246

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
H11360.pdf
Size:
1.57 MB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)