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Unraveling the role of ataxin-2 in metabolism

2017-04Journal article Restricted access
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dc.contributor.authorCarmo-Silva, Sara
dc.contributor.authorNóbrega, Clévio
dc.contributor.authorde Almeida, Luís Pereira
dc.contributor.authorCavadas, Cláudia
dc.date.accessioned2019-11-20T15:07:43Z
dc.date.available2019-11-20T15:07:43Z
dc.date.issued2017-04
dc.description.abstractAtaxin-2 is a polyglutamine protein implicated in several biological processes such as RNA metabolism and cytoskeleton reorganization. Ataxin-2 is highly expressed in various tissues including the hypothalamus, a brain region that controls food intake and energy balance. Ataxin-2 expression is influenced by nutritional status. Emerging studies discussed here now show that ataxin-2 deficiency correlates with insulin resistance and dyslipidemia, an action mediated via the mTOR pathway, suggesting that ataxin-2 might play key roles in metabolic homeostasis including body weight regulation, insulin sensitivity, and cellular stress responses. In this review we also discuss the relevance of ataxin-2 in the hypothalamic regulation of energy balance, and its potential as a therapeutic target in metabolic disorders such as obesity.
dc.description.sponsorshipFEDER (QREN) through Programa Mais Centro [CENTRO-07-ST24-FEDER-002006]
dc.description.sponsorshipFEDER (QREN) through Operational Programme Factors Competitiveness (COMPETE)
dc.description.sponsorshipNational Funds through FCT (Foundation for Science and Technology) [UID/NEU/04539/201, SFRH/BD/89035/2012]
dc.identifier.doi10.1016/j.tem.2016.12.006
dc.identifier.issn1043-2760
dc.identifier.urihttp://hdl.handle.net/10400.1/13182
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationUNRAVELING THE ROLE OF ATAXIN-2 IN THE HYPOTHALAMUS: FROM NEUROPEPTIDES REGULATION TO AGING
dc.subjectLength polyglutamine expansions
dc.subjectTerm olfactory habituation
dc.subjectGenome wide association
dc.subjectChain amino-acids
dc.subjectStress granules
dc.subjectSaccharomyces-cerevisiae
dc.subjectCaenorhabditis elegans
dc.subjectDrosophila homolog
dc.subjectProtein expression
dc.subjectGene expression
dc.titleUnraveling the role of ataxin-2 in metabolism
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUNRAVELING THE ROLE OF ATAXIN-2 IN THE HYPOTHALAMUS: FROM NEUROPEPTIDES REGULATION TO AGING
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FNEU%2F04539%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F89035%2F2012/PT
oaire.citation.endPage318
oaire.citation.issue4
oaire.citation.startPage309
oaire.citation.titleTrends in Endocrinology and Metabolism
oaire.citation.volume28
oaire.fundingStream5876
person.familyNameNóbrega
person.givenNameClévio
person.identifier.ciencia-idC510-7F41-BAF8
person.identifier.orcid0000-0002-8312-5292
person.identifier.ridM-6047-2013
person.identifier.scopus-author-id24473454000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscovery725ea6f8-1363-4cee-9cf2-5ac7303b3ba9
relation.isProjectOfPublicationb1188f0a-b959-4b99-b567-d052a725e24f
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relation.isProjectOfPublication.latestForDiscoveryb1188f0a-b959-4b99-b567-d052a725e24f

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