Repository logo
 
Publication

Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression

2021-09Journal article Open access
Simple item page
dc.contributor.authorFonseca, André
dc.contributor.authorVentura Ramalhete, Sara Maria
dc.contributor.authorMestre, André
dc.contributor.authorNeves, Ricardo
dc.contributor.authorMarreiros, Ana
dc.contributor.authorCastelo-Branco, Pedro
dc.date.accessioned2021-10-28T16:27:49Z
dc.date.available2021-10-28T16:27:49Z
dc.date.issued2021-09
dc.description.abstractColorectal cancer is one of the leading causes of cancer-related deaths worldwide. This complex disease still holds severe problems concerning diagnosis due to the high invasiveness nature of colonoscopy and the low accuracy of the alternative diagnostic methods. Additionally, patient heterogeneity even within the same stage is not properly reflected in the current stratification system. This scenario highlights the need for new biomarkers to improve non-invasive screenings and clinical management of patients. MicroRNAs (miRNAs) have emerged as good candidate biomarkers in cancer as they are stable molecules, easily measurable and detected in body fluids thus allowing for non-invasive diagnosis and/or prognosis. In this study, we performed an integrated analysis first using 4 different datasets (discovery cohorts) to identify miRNAs associated with colorectal cancer development, unveil their role in this disease by identifying putative targets and regulatory networks and investigate their ability to serve as biomarkers. We have identified 26 differentially expressed miRNAs which interact with frequently deregulated genes known to participate in commonly altered pathways in colorectal cancer. Most of these miRNAs have high diagnostic power, and their prognostic potential is evidenced by panels of 5 miRNAs able to predict the outcome of stage II and III colorectal cancer patients. Notably, 8 miRNAs were validated in three additional independent cohorts (validation cohorts) including a plasma cohort thus reinforcing the value of miRNAs as non-invasive biomarkers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.18632/aging.203556pt_PT
dc.identifier.issn1945-4589
dc.identifier.urihttp://hdl.handle.net/10400.1/17260
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherImpact Journalspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMicroRNAspt_PT
dc.subjectBiomarkerpt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectDiagnosispt_PT
dc.subjectPrognosispt_PT
dc.titleIdentification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expressionpt_PT
dc.title.alternativeIdentificação de biomarcadores associados ao câncer colorretal: uma análise integrada da expressão miRNApt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage22029pt_PT
oaire.citation.issue18pt_PT
oaire.citation.startPage21991pt_PT
oaire.citation.titleAgingpt_PT
oaire.citation.volume13pt_PT
person.familyNameFonseca
person.familyNameMestre
person.familyNamePires das Neves
person.familyNameMarreiros
person.familyNameCastelo-Branco
person.givenNameAndré Filipe Afonso de Sousa
person.givenNameAndré
person.givenNameRicardo Neves
person.givenNameAna
person.givenNamePedro
person.identifierhttps://scholar.google.pt/citations?user=QciBVB4AAAAJ&hl=en
person.identifier.ciencia-id0B1D-8695-6ADB
person.identifier.ciencia-idC113-BBFB-4848
person.identifier.ciencia-id3B1D-52BC-7AE4
person.identifier.ciencia-id9A12-9450-7051
person.identifier.ciencia-idE015-7F8F-5CA1
person.identifier.orcid0000-0001-6930-5409
person.identifier.orcid0000-0003-2291-6610
person.identifier.orcid0000-0001-9410-4772
person.identifier.orcid0000-0002-3453-3978
person.identifier.scopus-author-id57194785077
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc242bab5-7d06-4b31-9fae-98447f5e2b96
relation.isAuthorOfPublication593b5991-063a-4bcf-b560-94e899396b63
relation.isAuthorOfPublication6df32c06-616f-48a0-addd-1bd3225f97de
relation.isAuthorOfPublicationc0a8e5da-26ae-42a8-ab04-fa4df4356375
relation.isAuthorOfPublicationbb25b5ad-1769-42be-a7d3-8fe76215aa23
relation.isAuthorOfPublication.latestForDiscovery593b5991-063a-4bcf-b560-94e899396b63

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Identification of colorectal cancer associated.pdf
Size:
3.57 MB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)