Repository logo
 
Publication

Cancer stem cells in prostate cancer: implications for targeted therapy

2017Journal article Open access
Simple item page
dc.contributor.authorLeao, Ricardo
dc.contributor.authorDomingos, Célia
dc.contributor.authorFigueiredo, Arnaldo
dc.contributor.authorHamilton, Robert
dc.contributor.authorTabori, Uri
dc.contributor.authorCastelo-Branco, Pedro
dc.date.accessioned2018-12-07T14:58:23Z
dc.date.available2018-12-07T14:58:23Z
dc.date.issued2017
dc.description.abstractProstate cancer (PCa) is the most frequently diagnosed cancer in men and the second most common cause of cancer-related mortality among men in the developed world. Conventional anti-PCa therapies include surgery, radiation, hormonal ablation, and chemotherapy. Despite increasing efforts, these therapies are not effective for patients with advanced and/or metastatic disease. In most cases, cancer therapies fail due to an incomplete depletion of tumor cells, resulting in tumor relapse. The cancer stem cell (CSC) hypothesis is an emerging model that explains many of the molecular characteristics of oncological disease as well as the tendency of cancers to relapse, metastasize, and develop resistance to conventional therapies. CSCs are a reservoir of cancer cells that exhibit properties of self-renewal and the ability to reestablish the heterogeneous tumor cell population. The existence of PCa stem cells offers a theoretical explanation for many uncertainties regarding PCa and also for treatment resistance and disease progression once clinical cure is achieved. Therapies targeting CSCs might therefore lead to more effective cancer treatments, divergent from a traditional anti-proliferative approach, based on tumor bulk reduction accompanied by CSC-specific inhibition. Here, we focus on reviewing the historical perspective as well as concepts regarding stem cells and CSCs in PCa. In addition, we will report possible strategies and new clinical approaches that address the CSC-based concept of tumorigenesis in PCa. (C) 2017 S. Karger AG, Basel
dc.identifier.doi10.1159/000455160
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.urihttp://hdl.handle.net/10400.1/11996
dc.language.isoeng
dc.peerreviewedyes
dc.publisherKarger
dc.subjectEpithelial mesenchymal transition
dc.subjectStem progenitor cells
dc.subjectSignaling pathway
dc.subjectRat prostate
dc.subjectDifferentiation pathways
dc.subjectMonoclonal antibodies
dc.subjectKeratin expression
dc.subjectAndrogen receptor
dc.subjectInitiating cells
dc.subjectDrug resistance
dc.titleCancer stem cells in prostate cancer: implications for targeted therapy
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage136
oaire.citation.issue2
oaire.citation.startPage125
oaire.citation.titleUrologia Internationalis
oaire.citation.volume99
person.familyNameDomingos
person.familyNameCastelo-Branco
person.givenNameCélia
person.givenNamePedro
person.identifier.ciencia-idC410-E105-17DF
person.identifier.ciencia-idE015-7F8F-5CA1
person.identifier.orcid0000-0002-8828-1366
person.identifier.orcid0000-0002-3453-3978
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationc3f4f663-5714-4d31-8fff-41a5ff66ae75
relation.isAuthorOfPublicationbb25b5ad-1769-42be-a7d3-8fe76215aa23
relation.isAuthorOfPublication.latestForDiscoveryc3f4f663-5714-4d31-8fff-41a5ff66ae75

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Cancer Stem Cells in Prostate Cancer, Implications for Targeted Therapy.pdf
Size:
304.73 KB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)