Publication
Screening for acetylcholinesterase inhibition, lipid peroxidation inhibition and antioxidant activity of medicinal plants from Morocco
dc.contributor.author | Aazza, Smail | |
dc.contributor.author | El-Guendouz, Soukaina | |
dc.contributor.author | Miguel, Maria | |
dc.date.accessioned | 2023-01-12T13:39:57Z | |
dc.date.available | 2023-01-12T13:39:57Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Acetylcholinesterase (AChE), hydrolyzes acetylcholine to choline and acetate, thereby terminating this neurotransmitter effect at cholinergic synapses. Therefore, AChE inhibition is used for counterbalance the cholinergic deficit in Alzheimer's disease (AD) patients. In the present work, in order to find new plant acetylcholinesterase inhibitors, the hydroalcoholic extracts from seventeen medicinal plant species were screened for their acetylcholinesterase inhibition activity, as well as total phenolic (TPC) and flavonoids contents (TFC) and antioxidant activity using ORAC (Oxygen Radical Absorbance Capacity) assay, and their ability to inhibit lipid peroxidation. The results revealed that Rumex acetosa, Taraxacum officinale and Hypericum perforatum extracts possessing the highest TPC and TFC, were the most effective in terms of ORAC antioxidant activity, and acetylcholinesterase inhibition, in addition to their ability to inhibit liposomes peroxidation, suggesting that those plant species may provide a substantial source of secondary metabolites, which act as natural antioxidants and acetylcholinesterase inhibitors, and may be beneficial in the treatment of AD. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.doi | 10.37360/blacpma.23.22.1.1 | pt_PT |
dc.identifier.issn | 0717-7917 | |
dc.identifier.uri | http://hdl.handle.net/10400.1/18809 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | MS-Editions | pt_PT |
dc.relation | Mediterranean Institute for Agriculture, Environment and Development | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | Alzheimer | pt_PT |
dc.subject | Liposome peroxidation | pt_PT |
dc.subject | ORAC | pt_PT |
dc.subject | Rumex acetosa | pt_PT |
dc.subject | Taraxacum officinale | pt_PT |
dc.subject | Hypericum perforatum | pt_PT |
dc.title | Screening for acetylcholinesterase inhibition, lipid peroxidation inhibition and antioxidant activity of medicinal plants from Morocco | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.awardTitle | Mediterranean Institute for Agriculture, Environment and Development | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05183%2F2020/PT | |
oaire.citation.endPage | 18 | pt_PT |
oaire.citation.issue | 1 | pt_PT |
oaire.citation.startPage | 1 | pt_PT |
oaire.citation.title | Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas | pt_PT |
oaire.citation.volume | 22 | pt_PT |
oaire.fundingStream | 6817 - DCRRNI ID | |
person.familyName | Miguel | |
person.givenName | Maria da Graça | |
person.identifier.ciencia-id | 6110-6FE7-DF28 | |
person.identifier.orcid | 0000-0003-2507-4228 | |
person.identifier.scopus-author-id | 35562054500 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
relation.isAuthorOfPublication | 2507350f-9e60-4d4a-a096-53e58d93549c | |
relation.isAuthorOfPublication.latestForDiscovery | 2507350f-9e60-4d4a-a096-53e58d93549c | |
relation.isProjectOfPublication | 823bd652-ee6c-4479-91c5-06095bc37e9c | |
relation.isProjectOfPublication.latestForDiscovery | 823bd652-ee6c-4479-91c5-06095bc37e9c |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Screening for acetylcholinesterase inhibition, lipid peroxidation inhibition and antioxidant activity of medicinal plants from Morocco.pdf
- Size:
- 994.14 KB
- Format:
- Adobe Portable Document Format
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 3.46 KB
- Format:
- Item-specific license agreed upon to submission
- Description: