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Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion

2016-12Journal article Open access
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dc.contributor.authorRibeiro, Ana Luisa
dc.contributor.authorSilva, Rui D.
dc.contributor.authorFoyn, Havard
dc.contributor.authorTiago, Margarida N.
dc.contributor.authorRathore, Om
dc.contributor.authorArnesen, Thomas
dc.contributor.authorMartinho, Rui Goncalo
dc.date.accessioned2017-04-07T15:55:33Z
dc.date.available2017-04-07T15:55:33Z
dc.date.issued2016-12
dc.description.abstractThe gene separation anxiety (san) encodes Naa50/San, a N-terminal acetyltransferase required for chromosome segregation during mitosis. Although highly conserved among higher eukaryotes, the mitotic function of this enzyme is still poorly understood. Naa50/San was originally proposed to be required for centromeric sister chromatid cohesion in Drosophila and human cells, yet, more recently, it was also suggested to be a negative regulator of microtubule polymerization through internal acetylation of beta Tubulin. We used genetic and biochemical approaches to clarify the function of Naa50/San during development. Our work suggests that Naa50/San is required during tissue proliferation for the correct interaction between the cohesin subunits Scc1 and Smc3. Our results also suggest a working model where Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, and that this co-translational modification is subsequently required for the establishment and/or maintenance of sister chromatid cohesion.
dc.identifier.doi10.1038/srep39118
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/9157
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Publishing Group
dc.relationProtein targeting and N-terminal acetylation
dc.relationCentre for Biomedical Research
dc.relationREGULATION OF PRE-MRNA SPLICING DURING DROSOPHILA DEVELOPMENT
dc.relation.isbasedonWOS:000390088000001
dc.titleNaa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleProtein targeting and N-terminal acetylation
oaire.awardTitleCentre for Biomedical Research
oaire.awardTitleREGULATION OF PRE-MRNA SPLICING DURING DROSOPHILA DEVELOPMENT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-BQB%2F0712%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BID%2F0395%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F52428%2F2013/PT
oaire.citation.endPage39118
oaire.citation.startPage39118
oaire.citation.titleScientific Reports
oaire.citation.volume6
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
person.familyNameRathore
person.familyNameViegas Russo da Conceição Martinho
person.givenNameOm
person.givenNameRui Gonçalo
person.identifier.ciencia-idF31D-C783-3D89
person.identifier.orcid0000-0003-3858-557X
person.identifier.orcid0000-0002-1641-3403
person.identifier.ridM-7546-2013
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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