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Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family

2009Journal article Open Access
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dc.contributor.authorBelo, José A.
dc.contributor.authorSilva, Ana C.
dc.contributor.authorBorges, Ana
dc.contributor.authorFilipe, Mário
dc.contributor.authorBento, Margaret
dc.contributor.authorGonçalves, Lisa
dc.contributor.authorVitorino, Marta
dc.contributor.authorSalgueiro, Ana Marisa
dc.contributor.authorTexeira, Vera
dc.contributor.authorTavares, Ana T.
dc.contributor.authorMarques, Sara
dc.date.accessioned2018-12-07T14:58:35Z
dc.date.available2018-12-07T14:58:35Z
dc.date.issued2009
dc.description.abstractOne fundamental aspect of vertebrate embryonic development is the formation of the body plan. For this process, asymmetries have to be generated during early stages of development along the three main body axes: Anterior-Posterior, Dorso-Ventral and Left-Right. We have been studying the role of a novel class of molecules,the Cerberus/Dan gene family. These are dedicated secreted antagonists of three major signaling pathways: Nodal, BMP and Wnt. Our studies contribute to the current view that the fine tuning of signaling is controlled by a set of inhibitory molecules rather than by activators. In this context, the Cerberus-like molecules emerge as key players in the regulation and generation of asymmetries in the early vertebrate embryo.
dc.description.sponsorshipC.R.U.P; F.C.T.; IGC/Fundação Calouste Gulbenkian
dc.identifier.doi10.1387/ijdb.072297jb
dc.identifier.issn0214-6282
dc.identifier.urihttp://hdl.handle.net/10400.1/12103
dc.language.isoeng
dc.peerreviewedyes
dc.publisherU B C Press
dc.subjectAnterior primitive endoderm
dc.subjectMouse forebrain development
dc.subjectVisceral endoderm
dc.subjectNodal expression
dc.subjectXenopus embryos
dc.subjectChick-embryo
dc.subjectNeuralizing activity
dc.subjectLateral-inhibition
dc.subjectSpemanns organizer
dc.subjectSecreted proteins
dc.titleGenerating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1407
oaire.citation.issue08-out
oaire.citation.startPage1399
oaire.citation.titleInternational Journal of Developmental Biology
oaire.citation.volume53
person.familyNameBelo
person.familyNameBorges
person.familyNameBento Soares
person.familyNameVitorino
person.familyNameSalgueiro
person.familyNameMarques
person.givenNameJosé A.
person.givenNameAna
person.givenNameMargaret
person.givenNameMarta
person.givenNameAna Marisa
person.givenNameSara
person.identifier.ciencia-idBF13-08E9-25E6
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person.identifier.ciencia-id4615-FF5B-E951
person.identifier.ciencia-idBB17-0F5D-A4FB
person.identifier.orcid0000-0001-7384-0949
person.identifier.orcid0000-0002-2572-6823
person.identifier.orcid0000-0001-8563-8975
person.identifier.orcid0000-0002-9694-1029
person.identifier.orcid0000-0001-6784-5612
person.identifier.ridF-4444-2012
person.identifier.ridU-9947-2018
person.identifier.ridF-8601-2014
person.identifier.scopus-author-id6602141392
person.identifier.scopus-author-id57190066063
person.identifier.scopus-author-id15769915500
rcaap.rightsopenAccess
rcaap.typearticle
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